UNASSIGNED: We searched the relevant literature in PubMed, Embase and Cochrane. Conventional and network meta-analyses were performed for sensitivity, specificity, Youden index (YI), and the area under the summary receiver operator characteristic curve (AUC).
UNASSIGNED: Fifteen studies involving 2031 NAFLD participants were included in this meta-analysis. When detecting early-stage NAFLD-related HCC, GALAD score and DCP process excellent performance. The sensitivity and AUC of DCP (0.60, 0.74, respectively) were higher than AFP (0.34, 0.59, respectively). The network meta-analysis showed that DCP and GALAD score had similar performance. In detecting all-stage NAFLD-related HCC, GALAD score (sensitivity = 0.87; YI = 0.77) performed better than AFP (sensitivity = 0.56; YI = 0.50), AFP-L3 (sensitivity = 0.39; YI = 0.36) and DCP (sensitivity = 0.73; YI = 0.62). Network meta-analysis obtained consistent results with conventional meta-analysis.
UNASSIGNED: Due to the lower cost-effectiveness, DCP was more suitable for detecting early NAFLD-related HCC. AFP could be used in detecting all-stage NAFLD-related HCC.
■我们搜索了PubMed中的相关文献,Embase和Cochrane.进行了常规和网络荟萃分析的敏感性,特异性,尤登指数(YI),和汇总受试者操作特征曲线(AUC)下的面积。
■本荟萃分析纳入了15项研究,涉及2031名NAFLD参与者。当检测早期NAFLD相关HCC时,GALAD成绩和DCP工艺表现优秀。DCP的灵敏度和AUC(分别为0.60、0.74)高于AFP(分别为0.34、0.59)。网络荟萃分析显示DCP和GALAD评分具有相似的表现。在检测所有阶段NAFLD相关HCC时,GALAD评分(敏感度=0.87;YI=0.77)优于AFP(敏感度=0.56;YI=0.50),AFP-L3(灵敏度=0.39;YI=0.36)和DCP(灵敏度=0.73;YI=0.62)。网络荟萃分析获得了与常规荟萃分析一致的结果。
■由于成本效益较低,DCP更适合检测早期NAFLD相关HCC。AFP可用于检测所有阶段NAFLD相关的HCC。