Abstract：
UNASSIGNED: The incidence of nonalcoholic fatty liver disease (NAFLD)-related hepatocellular carcinoma (HCC) is increasing globally. We aimed to assess the performance of alpha-fetoprotein (AFP), AFP-L3, des-gamma-carboxy prothrombin (DCP), and GALAD score in detecting NAFLD-related HCC.
UNASSIGNED: We searched the relevant literature in PubMed, Embase and Cochrane. Conventional and network meta-analyses were performed for sensitivity, specificity, Youden index (YI), and the area under the summary receiver operator characteristic curve (AUC).
UNASSIGNED: Fifteen studies involving 2031 NAFLD participants were included in this meta-analysis. When detecting early-stage NAFLD-related HCC, GALAD score and DCP process excellent performance. The sensitivity and AUC of DCP (0.60, 0.74, respectively) were higher than AFP (0.34, 0.59, respectively). The network meta-analysis showed that DCP and GALAD score had similar performance. In detecting all-stage NAFLD-related HCC, GALAD score (sensitivity = 0.87; YI = 0.77) performed better than AFP (sensitivity = 0.56; YI = 0.50), AFP-L3 (sensitivity = 0.39; YI = 0.36) and DCP (sensitivity = 0.73; YI = 0.62). Network meta-analysis obtained consistent results with conventional meta-analysis.
UNASSIGNED: Due to the lower cost-effectiveness, DCP was more suitable for detecting early NAFLD-related HCC. AFP could be used in detecting all-stage NAFLD-related HCC.
UNASSIGNED: We searched the relevant literature in PubMed, Embase and Cochrane. Conventional and network meta-analyses were performed for sensitivity, specificity, Youden index (YI), and the area under the summary receiver operator characteristic curve (AUC).
UNASSIGNED: Fifteen studies involving 2031 NAFLD participants were included in this meta-analysis. When detecting early-stage NAFLD-related HCC, GALAD score and DCP process excellent performance. The sensitivity and AUC of DCP (0.60, 0.74, respectively) were higher than AFP (0.34, 0.59, respectively). The network meta-analysis showed that DCP and GALAD score had similar performance. In detecting all-stage NAFLD-related HCC, GALAD score (sensitivity = 0.87; YI = 0.77) performed better than AFP (sensitivity = 0.56; YI = 0.50), AFP-L3 (sensitivity = 0.39; YI = 0.36) and DCP (sensitivity = 0.73; YI = 0.62). Network meta-analysis obtained consistent results with conventional meta-analysis.
UNASSIGNED: Due to the lower cost-effectiveness, DCP was more suitable for detecting early NAFLD-related HCC. AFP could be used in detecting all-stage NAFLD-related HCC.
摘要：
■非酒精性脂肪性肝病（NAFLD）相关的肝细胞癌（HCC）的发病率正在全球增加。我们的目的是评估甲胎蛋白（AFP）的性能，AFP-L3，des-γ-羧基凝血酶原（DCP），和GALAD评分检测NAFLD相关HCC。
■我们搜索了PubMed中的相关文献，Embase和Cochrane.进行了常规和网络荟萃分析的敏感性，特异性，尤登指数(YI)，和汇总受试者操作特征曲线(AUC)下的面积。
■本荟萃分析纳入了15项研究，涉及2031名NAFLD参与者。当检测早期NAFLD相关HCC时，GALAD成绩和DCP工艺表现优秀。DCP的灵敏度和AUC（分别为0.60、0.74）高于AFP（分别为0.34、0.59）。网络荟萃分析显示DCP和GALAD评分具有相似的表现。在检测所有阶段NAFLD相关HCC时，GALAD评分(敏感度=0.87;YI=0.77)优于AFP(敏感度=0.56;YI=0.50),AFP-L3(灵敏度=0.39;YI=0.36)和DCP(灵敏度=0.73;YI=0.62)。网络荟萃分析获得了与常规荟萃分析一致的结果。
■由于成本效益较低，DCP更适合检测早期NAFLD相关HCC。AFP可用于检测所有阶段NAFLD相关的HCC。
■我们搜索了PubMed中的相关文献，Embase和Cochrane.进行了常规和网络荟萃分析的敏感性，特异性，尤登指数(YI)，和汇总受试者操作特征曲线(AUC)下的面积。
■本荟萃分析纳入了15项研究，涉及2031名NAFLD参与者。当检测早期NAFLD相关HCC时，GALAD成绩和DCP工艺表现优秀。DCP的灵敏度和AUC（分别为0.60、0.74）高于AFP（分别为0.34、0.59）。网络荟萃分析显示DCP和GALAD评分具有相似的表现。在检测所有阶段NAFLD相关HCC时，GALAD评分(敏感度=0.87;YI=0.77)优于AFP(敏感度=0.56;YI=0.50),AFP-L3(灵敏度=0.39;YI=0.36)和DCP(灵敏度=0.73;YI=0.62)。网络荟萃分析获得了与常规荟萃分析一致的结果。
■由于成本效益较低，DCP更适合检测早期NAFLD相关HCC。AFP可用于检测所有阶段NAFLD相关的HCC。
