PDF(Pubmed)
Abstract：
A 6 year-old spayed female Poodle presented with a mandibular mass. Radiographic examination revealed osteolysis from the right mandibular canine to the fourth premolar, along with horizontal bone loss and dorsal displacement of the right mandibular first and second premolars. Skull cone beam computed tomography revealed osteolysis at the level of the right mandibular canine and fourth premolar. A destructive bone lesion was observed in the apical area of the right mandibular canine, with mass invasion of the interradicular bone of the right mandibular first molar near the mandibular canal. Consequently, unilateral total mandibulectomy and skin flap surgery were performed. Histopathological examination revealed poorly demarcated and infiltrative neoplastic epithelial cells that formed small islands and trabeculae. Neoplastic cells exhibited the malignant features of cytological atypia and high mitotic activity. Furthermore, the neoplastic epithelial cells frequently showed ghost cell changes and were diagnosed as ghost cell odontogenic carcinoma (GCOC). The dog was followed up for 1 year, during which no severe complications or local recurrence was observed, except for slight mandibular drift, tongue protrusion, and drooling. This case report describes the clinical features, diagnostic imaging, and histologic features of an unreported GCOC in a dog and the favorable outcome following surgical resection.
摘要：
一只6岁的雌性贵宾犬出现下颌肿块。X线检查显示从右侧下颌犬到第四前磨牙的骨溶解，伴随着右下颌第一和第二前磨牙的水平骨丢失和背侧移位。颅骨锥形束计算机断层扫描显示右下颌犬和第四前磨牙的骨质溶解。在右下颌犬的顶端区域观察到破坏性的骨病变，下颌管附近的右下颌第一磨牙的神经根间骨大量侵入。因此,进行单侧全颌骨切除术和皮瓣手术。组织病理学检查显示，形成小岛和小梁的界限和浸润性肿瘤上皮细胞。肿瘤细胞表现出细胞学异型性和高有丝分裂活性的恶性特征。此外，肿瘤上皮细胞常表现为鬼细胞改变，被诊断为鬼细胞牙源性癌（GCOC）。这只狗被跟踪了一年，在此期间，没有观察到严重的并发症或局部复发，除了轻微的下颌漂移,舌头突出，流口水.此病例报告描述了临床特征，诊断成像,和未报告的狗GCOC的组织学特征以及手术切除后的有利结果。
