PDF(Pubmed)
Abstract：
Patients receiving allogeneic hematopoietic stem cell transplant may experience graft-versus-host disease (GVHD) in which donor immune cells cause an immune reaction in host tissues. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines are highly effective in prevention of severe coronavirus-2019 (COVID-19) disease, but the vaccine can result in immune activation and GVHD. Herein, we report 4 cases of oral manifestations that may have been stimulated by COVID-19 or vaccination with Pfizer or Moderna vaccines. We believe this study is the first to report oral changes driven by an inflammatory/immune mechanism leading to oral symptomatic cGVHD. The clinical impact of this study is early recognition and appropriate management of oral symptomatic cGVHD following COVID-19 disease or SARS-CoV-2 vaccination.
摘要：
接受异基因造血干细胞移植的患者可能会经历移植物抗宿主病（GVHD），其中供体免疫细胞在宿主组织中引起免疫反应。严重急性呼吸道综合征冠状病毒-2（SARS-CoV-2）疫苗在预防严重冠状病毒-2019（COVID-19）疾病方面非常有效，但是疫苗可以导致免疫激活和GVHD。在这里，我们报告了4例可能由COVID-19或辉瑞或Moderna疫苗刺激的口腔表现。我们相信这项研究是第一个报告由炎症/免疫机制驱动的口腔变化导致的口部症状性cGVHD。这项研究的临床影响是在COVID-19疾病或SARS-CoV-2疫苗接种后早期识别和适当管理口腔症状性cGVHD。
