PDF(Pubmed)
Abstract：
UNASSIGNED: Mast cells influence tumour growth, neo-angiogenesis and the propensity for metastasis by contributing to innate and adaptive immune responses in the tumour microenvironment. The number of mast cells has increased in various malignant tumours and their abundance has been associated with either a favourable or unfavourable prognosis. This study investigated the significant difference in stromal mast cell density among multiple prognostic factor groups in invasive breast carcinoma.
UNASSIGNED: CD117 (c-KIT) antibodies were used to stain 160 formalin-fixed and paraffin-embedded invasive breast carcinoma tissues to demonstrate the presence of mast cells. Then the labelled mast cells were counted in 10 fields at 400× magnification and the mean value was used to represent the mast cell density.
UNASSIGNED: The demographic distribution revealed that most patients were 40 years old or older (92.5%) and of Malay ethnicity (66.3%). With regard to prognostic factors, the most prevalent subtype was invasive carcinoma of no special type (80.6%), followed by tumour grade 3 (41.3%), T2 tumour size (63.1%), N0 lymph node stage (51.3%), presence of lymphovascular invasion (59.4%), positive oestrogen (64.4%) and progesterone receptors (53.1%), and negative human epidermal growth factor receptor 2 (HER2) expression (75.0%). However, there was no significant difference in stromal mast cell density among the different demographic and prognostic factor groups in invasive breast carcinoma.
UNASSIGNED: The findings from this study suggest that stromal mast cells do not play a significant role in preventing or promoting tumour growth in invasive breast carcinoma.
UNASSIGNED: CD117 (c-KIT) antibodies were used to stain 160 formalin-fixed and paraffin-embedded invasive breast carcinoma tissues to demonstrate the presence of mast cells. Then the labelled mast cells were counted in 10 fields at 400× magnification and the mean value was used to represent the mast cell density.
UNASSIGNED: The demographic distribution revealed that most patients were 40 years old or older (92.5%) and of Malay ethnicity (66.3%). With regard to prognostic factors, the most prevalent subtype was invasive carcinoma of no special type (80.6%), followed by tumour grade 3 (41.3%), T2 tumour size (63.1%), N0 lymph node stage (51.3%), presence of lymphovascular invasion (59.4%), positive oestrogen (64.4%) and progesterone receptors (53.1%), and negative human epidermal growth factor receptor 2 (HER2) expression (75.0%). However, there was no significant difference in stromal mast cell density among the different demographic and prognostic factor groups in invasive breast carcinoma.
UNASSIGNED: The findings from this study suggest that stromal mast cells do not play a significant role in preventing or promoting tumour growth in invasive breast carcinoma.
摘要：
■肥大细胞影响肿瘤生长，通过促进肿瘤微环境中的先天和适应性免疫反应，新血管生成和转移倾向。在各种恶性肿瘤中，肥大细胞的数量有所增加，并且它们的丰度与有利或不利的预后有关。这项研究调查了浸润性乳腺癌中多个预后因素组之间基质肥大细胞密度的显着差异。
CD117(c-KIT)抗体用于对160个福尔马林固定和石蜡包埋的浸润性乳腺癌组织进行染色以证明肥大细胞的存在。然后以400倍放大倍数在10个视野中计数标记的肥大细胞，并使用平均值表示肥大细胞密度。
■人口统计学分布显示，大多数患者为40岁或以上（92.5%）和马来人（66.3%）。关于预后因素，最常见的亚型是非特殊类型的浸润性癌（80.6%），其次是肿瘤3级（41.3%），T2肿瘤大小（63.1%），N0淋巴结分期（51.3%），存在淋巴管浸润（59.4％），雌激素阳性（64.4%）和孕激素受体阳性（53.1%），人表皮生长因子受体2(HER2)表达阴性(75.0%)。然而,在浸润性乳腺癌中，不同的人口统计学和预后因素组之间的基质肥大细胞密度没有显着差异。
■这项研究的结果表明，基质肥大细胞在阻止或促进浸润性乳腺癌的肿瘤生长中没有发挥重要作用。
CD117(c-KIT)抗体用于对160个福尔马林固定和石蜡包埋的浸润性乳腺癌组织进行染色以证明肥大细胞的存在。然后以400倍放大倍数在10个视野中计数标记的肥大细胞，并使用平均值表示肥大细胞密度。
■人口统计学分布显示，大多数患者为40岁或以上（92.5%）和马来人（66.3%）。关于预后因素，最常见的亚型是非特殊类型的浸润性癌（80.6%），其次是肿瘤3级（41.3%），T2肿瘤大小（63.1%），N0淋巴结分期（51.3%），存在淋巴管浸润（59.4％），雌激素阳性（64.4%）和孕激素受体阳性（53.1%），人表皮生长因子受体2(HER2)表达阴性(75.0%)。然而,在浸润性乳腺癌中，不同的人口统计学和预后因素组之间的基质肥大细胞密度没有显着差异。
■这项研究的结果表明，基质肥大细胞在阻止或促进浸润性乳腺癌的肿瘤生长中没有发挥重要作用。
