PDF(Pubmed)
Abstract：
Age-related immunosenescence is characterized by changes in immune cell subsets and is associated with mortality. However, since immunosenescence is associated with other concurrent age-related changes such as inflammation and multi-organ dysfunction, it is unclear whether the association between age-related immunosenescence and mortality is independent of other concurrent age-related changes. To address these limitations, we evaluated the independent association between immune cell subsets and mortality after adjustment for age-related inflammation and biologic age.
Data for this study was obtained from the 2016 interview of the Health and Retirement Study (N=6802). Cox proportional hazards regression models were used to estimate the association between 25 immune cell subsets (11 T-cell subsets, 4 B-cell subsets, 3 monocyte subsets, 3 natural killer cell subsets, 3 dendritic cell subsets, and neutrophils) and 4-year mortality adjusting for covariates such as the Klemera-Doubal algorithm biological age, chronological age, gender, race/ethnicity, BMI, smoking status, comorbidity index, CMV seropositivity, and inflammatory latent variable comprising C-reactive protein, and 4 cytokines (interleukin-10, interleukin-1 receptor antagonist, interleukin-6, and soluble tumor necrosis factor).
Four hundred and seventy-six participants died during the study period with an overall median follow up time of 2.5 years. After controlling for covariates and adjustment for sample-weights, total T cells [HR: 0.86, p=0.004], NK CD56LO cells [HR: 0.88, p=0.005], and neutrophils [HR: 1.22, p=0.004] were significantly associated with mortality.
These findings support the idea that an aging immune system is associated with short-term mortality independent of age-related inflammation or other age-related measures of physiological dysfunction. If replicated in other external cohorts, these findings could identify novel targets for both monitoring and intervention to reduce the age-related mortality.
Data for this study was obtained from the 2016 interview of the Health and Retirement Study (N=6802). Cox proportional hazards regression models were used to estimate the association between 25 immune cell subsets (11 T-cell subsets, 4 B-cell subsets, 3 monocyte subsets, 3 natural killer cell subsets, 3 dendritic cell subsets, and neutrophils) and 4-year mortality adjusting for covariates such as the Klemera-Doubal algorithm biological age, chronological age, gender, race/ethnicity, BMI, smoking status, comorbidity index, CMV seropositivity, and inflammatory latent variable comprising C-reactive protein, and 4 cytokines (interleukin-10, interleukin-1 receptor antagonist, interleukin-6, and soluble tumor necrosis factor).
Four hundred and seventy-six participants died during the study period with an overall median follow up time of 2.5 years. After controlling for covariates and adjustment for sample-weights, total T cells [HR: 0.86, p=0.004], NK CD56LO cells [HR: 0.88, p=0.005], and neutrophils [HR: 1.22, p=0.004] were significantly associated with mortality.
These findings support the idea that an aging immune system is associated with short-term mortality independent of age-related inflammation or other age-related measures of physiological dysfunction. If replicated in other external cohorts, these findings could identify novel targets for both monitoring and intervention to reduce the age-related mortality.
摘要：
■年龄相关的免疫衰老的特征在于免疫细胞亚群的变化，并与死亡率相关。然而,由于免疫衰老与其他并发的年龄相关变化有关，如炎症和多器官功能障碍，目前尚不清楚年龄相关性免疫衰老和死亡率之间的关联是否独立于其他同时发生的年龄相关性变化.为了解决这些限制，我们在校正了年龄相关性炎症和生物学年龄后,评估了免疫细胞亚群与死亡率之间的独立关联.
■本研究的数据来自2016年对健康与退休研究的访谈（N=6802）。Cox比例风险回归模型用于估计25个免疫细胞亚群（11个T细胞亚群，4个B细胞亚群，3个单核细胞亚群，3个自然杀伤细胞亚群，3树突状细胞亚群，和中性粒细胞）和4年死亡率调整协变量，如Klemera-Doubal算法生物年龄，实际年龄,性别,种族/民族,BMI,吸烟状况,合并症指数，CMV血清阳性,和包含C反应蛋白的炎症潜在变量，和4种细胞因子（白细胞介素-10，白细胞介素-1受体拮抗剂，白细胞介素6和可溶性肿瘤坏死因子）。
■四百七十六名参与者在研究期间死亡，总体中位随访时间为2.5年。在控制协变量和调整样本权重之后，总T细胞[HR：0.86，p=0.004]，NKCD56LO细胞[HR：0.88，p=0.005]，和中性粒细胞[HR:1.22,p=0.004]与死亡率显著相关.
■这些发现支持了衰老的免疫系统与短期死亡率相关的观点，而与年龄相关的炎症或其他与年龄相关的生理功能障碍指标无关。如果在其他外部队列中复制，这些发现可以确定新的监测和干预目标,以降低与年龄相关的死亡率.
■本研究的数据来自2016年对健康与退休研究的访谈（N=6802）。Cox比例风险回归模型用于估计25个免疫细胞亚群（11个T细胞亚群，4个B细胞亚群，3个单核细胞亚群，3个自然杀伤细胞亚群，3树突状细胞亚群，和中性粒细胞）和4年死亡率调整协变量，如Klemera-Doubal算法生物年龄，实际年龄,性别,种族/民族,BMI,吸烟状况,合并症指数，CMV血清阳性,和包含C反应蛋白的炎症潜在变量，和4种细胞因子（白细胞介素-10，白细胞介素-1受体拮抗剂，白细胞介素6和可溶性肿瘤坏死因子）。
■四百七十六名参与者在研究期间死亡，总体中位随访时间为2.5年。在控制协变量和调整样本权重之后，总T细胞[HR：0.86，p=0.004]，NKCD56LO细胞[HR：0.88，p=0.005]，和中性粒细胞[HR:1.22,p=0.004]与死亡率显著相关.
■这些发现支持了衰老的免疫系统与短期死亡率相关的观点，而与年龄相关的炎症或其他与年龄相关的生理功能障碍指标无关。如果在其他外部队列中复制，这些发现可以确定新的监测和干预目标,以降低与年龄相关的死亡率.
