Data for this study was obtained from the 2016 interview of the Health and Retirement Study (N=6802). Cox proportional hazards regression models were used to estimate the association between 25 immune cell subsets (11 T-cell subsets, 4 B-cell subsets, 3 monocyte subsets, 3 natural killer cell subsets, 3 dendritic cell subsets, and neutrophils) and 4-year mortality adjusting for covariates such as the Klemera-Doubal algorithm biological age, chronological age, gender, race/ethnicity, BMI, smoking status, comorbidity index, CMV seropositivity, and inflammatory latent variable comprising C-reactive protein, and 4 cytokines (interleukin-10, interleukin-1 receptor antagonist, interleukin-6, and soluble tumor necrosis factor).
Four hundred and seventy-six participants died during the study period with an overall median follow up time of 2.5 years. After controlling for covariates and adjustment for sample-weights, total T cells [HR: 0.86, p=0.004], NK CD56LO cells [HR: 0.88, p=0.005], and neutrophils [HR: 1.22, p=0.004] were significantly associated with mortality.
These findings support the idea that an aging immune system is associated with short-term mortality independent of age-related inflammation or other age-related measures of physiological dysfunction. If replicated in other external cohorts, these findings could identify novel targets for both monitoring and intervention to reduce the age-related mortality.
■本研究的数据来自2016年对健康与退休研究的访谈(N=6802)。Cox比例风险回归模型用于估计25个免疫细胞亚群(11个T细胞亚群,4个B细胞亚群,3个单核细胞亚群,3个自然杀伤细胞亚群,3树突状细胞亚群,和中性粒细胞)和4年死亡率调整协变量,如Klemera-Doubal算法生物年龄,实际年龄,性别,种族/民族,BMI,吸烟状况,合并症指数,CMV血清阳性,和包含C反应蛋白的炎症潜在变量,和4种细胞因子(白细胞介素-10,白细胞介素-1受体拮抗剂,白细胞介素6和可溶性肿瘤坏死因子)。
■四百七十六名参与者在研究期间死亡,总体中位随访时间为2.5年。在控制协变量和调整样本权重之后,总T细胞[HR:0.86,p=0.004],NKCD56LO细胞[HR:0.88,p=0.005],和中性粒细胞[HR:1.22,p=0.004]与死亡率显著相关.
■这些发现支持了衰老的免疫系统与短期死亡率相关的观点,而与年龄相关的炎症或其他与年龄相关的生理功能障碍指标无关。如果在其他外部队列中复制,这些发现可以确定新的监测和干预目标,以降低与年龄相关的死亡率.