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Abstract：
Background Poor nutritional status may lead to longer hospital stays, increased mortality and morbidity, increased cost, and higher suffering. Nosocomial infections (NI) are a global health concern, and several risk factors are associated with their higher incidence. This study aimed to reveal that compromised nutritional status is one of the risk factors for developing NIs. Methodology The study was conducted in a tertiary care hospital in Pune, India. This was a prospective cohort study with a sample size of 200 hospitalized participants. Data collection was based on standard tools and structured forms which had two parts. In the first part, the assessment of nutritional status was done for which patients were categorized into two groups, namely, well-nourished and undernourished. Additionally, biochemical parameters (serum albumin) were also assessed. The second part included a follow-up of participants to evaluate the development of NIs including their laboratory investigation. Results were analyzed statistically using R software. Results Among 200 participants, 60 were female, of whom 15% developed NIs. Of the 140 males, 8% had NIs. Among 200 participants, 101 (51%) were well-nourished, of whom two (2%) developed NIs. Of the 99 (49%) undernourished participants, 18 (18%) had NIs. Those who were undernourished (univariate relative risk = 6.10, 95% confidence interval) were more prone to developing NIs compared to the well-nourished group. Conclusions NIs are widespread globally but are less studied and given less emphasis in developing countries. This study reports various types of NIs along with their incidence in well-nourished and undernourished groups. The incidence of NI observed in this study may reflect the higher severity of illness, age, poor nutritional status, and longer hospital stays. Identifying risk factors that can contribute to developing NI may help in their prevention by maximizing patient safety.
摘要：
背景营养不良可能导致住院时间延长，死亡率和发病率增加，成本增加,更高的痛苦。医院感染(NI)是全球健康问题，几个危险因素与它们的较高发病率有关。这项研究旨在揭示营养状况受损是发展NIs的风险因素之一。方法这项研究是在浦那的一家三级医院进行的，印度。这是一项前瞻性队列研究，样本量为200名住院参与者。数据收集基于标准工具和结构化形式，分为两个部分。在第一部分,进行营养状况评估，将患者分为两组，即,营养充足和营养不良。此外,还评估了生化指标(血清白蛋白).第二部分包括对参与者的随访，以评估NI的发展，包括他们的实验室调查。结果采用R软件进行统计学分析。结果在200名参与者中，60是女性，其中15%开发了NIs。140名男性中,8%有NIs。在200名参与者中，101（51％）营养良好，其中两个(2%)开发了NIs。在99名(49%)营养不良的参与者中，18（18%）有NIs。与营养良好的组相比，那些营养不良的人（单变量相对风险=6.10，95％置信区间）更容易发生NI。结论NI在全球范围内很普遍，但在发展中国家研究较少，重视程度较低。这项研究报告了营养充足和营养不良人群中各种类型的NIs及其发病率。在这项研究中观察到的NI的发生率可能反映出疾病的严重程度更高，年龄,营养状况差，住院时间更长。确定可能导致NI发展的风险因素可能有助于通过最大程度地提高患者安全性来预防NI。
