PDF(Pubmed)
Abstract：
Adenocarcinoma of the gallbladder is the most common gallbladder carcinoma. But lymphoid stroma in gallbladder carcinoma is one of the rarest presentations. A unique case of gallbladder adenocarcinoma with lymphoid stroma in a 47-year-old female is presented in this report. The surgically resected gallbladder demonstrated invasive adenocarcinoma with lymphoid stroma, though it was radiologically diagnosed as xanthogranulomatous cholecystitis. Adenocarcinoma was immunohistochemically positive for pancytokeratin (AE1/AE3), cytokeratin 7 (CK7), cytokeratin 20 (CK20), and carcinoembryonic antigen (CEA). Lymphoid stroma was positive for CD45, where B-cell zones were CD20 and CD79a positive, and T-cell zones were CD3 positive, with a larger T-cell subset being positive for CD4 than CD8. This is the fourth reported case of gallbladder adenocarcinoma with lymphoid stroma, which needs to be studied for pathogenesis, prognosis, and future therapy, if any.
摘要：
胆囊癌是最常见的胆囊癌。但是胆囊癌中的淋巴间质是最罕见的表现之一。本报告介绍了一名47岁女性的胆囊腺癌伴淋巴间质的独特病例。手术切除的胆囊显示浸润性腺癌伴淋巴间质，尽管放射学诊断为黄色肉芽肿性胆囊炎。腺癌免疫组织化学检查为全细胞角蛋白（AE1/AE3）阳性，细胞角蛋白7（CK7），细胞角蛋白20（CK20），和癌胚抗原（CEA）。淋巴间质CD45阳性，其中B细胞区CD20和CD79a阳性，T细胞区为CD3阳性，T细胞亚群的CD4比CD8呈阳性。这是第4例胆囊腺癌伴淋巴间质，这需要研究发病机理，预后,和未来的治疗，如果有的话。
