PDF(Pubmed)
Abstract：
Background: Intravenous thrombolysis is commonly used in the treatment of acute ischemic stroke damage. The existing thrombolytic drugs still suffer significant shortcomings, including a limited fibrin specificity and bleeding complications. Ferulic acid can directly bind the key thrombus enzymes and target to blood clots, suggesting its thrombolytic potency that may be beneficial with thrombolytic potency for the treatment of acute ischemic stroke damage. Objective: The purpose of this systematic review and meta-analysis was to evaluate the efficacy of ferulic acid in the treatment of acute ischemic stroke injury in rats and its potential mechanism of action. Materials and methods: We conducted a literature search in six databases, including CNKI, up to July 2023. Results: Sixteen trials were included in the meta-analysis, which demonstrated that ferulic acid significantly reduced infarct size, neurological deficit score, apoptosis index, cleaved caspase-3, and cytochrome C levels (all p < 0.05). In addition, ferulic acid significantly increased the levels of phosphorylated Akt, mitochondrial Bcl-xL/Bax, phosphorylated astrocyte PEA15, hippocampal calcium binding protein, and mitochondrial Bcl-2/Bax ratio (all p < 0.05). Conclusion: This study demonstrates that ferulic acid protects against acute ischemic stroke injury in rats by inhibiting ischemia-induced excitotoxicity, inflammatory response, and apoptosis.
摘要：
背景：静脉溶栓是治疗急性缺血性卒中损害的常用方法。现有的溶栓药物仍存在明显的缺陷,包括有限的纤维蛋白特异性和出血并发症。阿魏酸可以直接结合关键的血栓酶，靶向血凝块，提示其溶栓效力可能与溶栓效力有益于急性缺血性卒中损害的治疗。目的:系统评价阿魏酸治疗大鼠急性缺血性脑卒中损伤的疗效及其潜在作用机制。材料和方法：我们在六个数据库中进行了文献检索，包括CNKI,到2023年7月。结果：16项试验纳入荟萃分析，这表明阿魏酸显著减少梗死面积，神经功能缺损评分,凋亡指数,切割的胱天蛋白酶-3和细胞色素C水平(所有p<0.05)。此外,阿魏酸显著增加磷酸化Akt的水平，线粒体Bcl-xL/Bax,磷酸化星形胶质细胞PEA15，海马钙结合蛋白，和线粒体Bcl-2/Bax比值(均p<0.05)。结论:阿魏酸通过抑制缺血兴奋毒性对大鼠急性缺血性脑卒中损伤有保护作用。炎症反应，和凋亡。
