Abstract：
The delivery of Helicobacter pylori CagA into host cells was long believed to occur through the integrin cell surface receptors. However, the role of CEACAM receptors has recently been highlighted, instead. Here, we have categorized the existing experimental evidence according to whether deletion, upregulation, downregulation, or inhibition of the target ligands (T4SS or HopQ) or receptors (integrins or CEACAMs), result in alterations in CagA phosphorylation, cell elongation, or IL-8 production. According to our analysis, the statistics favor the essence of most of the T4SS constituents and the involvement of HopQ adhesin in all three functions. Concerning the integrin family, the collected data is controversial, but yielding towards it being dispensable or involved in CagA translocation. Yet, regarding cell elongation, more events are showing β1 integrin being involved, than αvβ4 being inhibitory. Concerning IL-8 secretion, again there are more events showing α5, β1 and β6 integrins to be involved, than those showing inhibitory roles for β1, β4 and β6 integrins. Finally, CEACAM 1, 3, and 5 are identified as mostly essential or involved in CagA phosphorylation, whereasCEACAM 4, 7, and 8 are found dispensable and CEACAM6 is under debate. Conversely, CEACAM1, 5 and 6 appear mostly dispensable for cell elongation. Noteworthy is the choice of cell type, bacterial strain, multiplicity and duration of infection, as well as the sensitivity of the detection methods, all of which can affect the variably obtained results.
摘要：
长期以来,人们认为幽门螺杆菌CagA进入宿主细胞是通过整联蛋白细胞表面受体进行的。然而,CEACAM受体的作用最近被强调，相反。这里,我们根据是否删除对现有的实验证据进行了分类，上调,下调,或抑制靶配体（T4SS或HopQ）或受体（整联蛋白或CEACAM），导致CagA磷酸化的改变，细胞伸长，或IL-8生产。根据我们的分析,统计数据支持大多数T4SS成分的本质以及HopQadhesin在所有三个功能中的参与。关于整合素家族，收集的数据是有争议的，但向它屈服是可有可无的或参与CagA易位。然而，关于细胞伸长，更多的事件显示β1整合素参与其中，比αvβ4具有抑制性。关于IL-8分泌，再次有更多的事件显示α5，β1和β6整合素参与，而不是那些对β1、β4和β6整合素显示抑制作用的人。最后,CEACAM1、3和5被鉴定为主要必需或参与CagA磷酸化，其中CEACAM4、7和8被发现是可有可无的，CEACAM6正在辩论中。相反，CEACAM1、5和6似乎对细胞伸长几乎是可有可无的。值得注意的是细胞类型的选择，细菌菌株，感染的多样性和持续时间，以及检测方法的灵敏度，所有这些都会影响不同获得的结果。
