Abstract：
Tessier clefts are skeletal and soft tissue abnormalities of a neonate\'s facial structures. They could be classified as syndromic and non-syndromic clefts, which can be attributed to disruptions in fetal development and genetic mutations, respectively. Reported cases of these clefts typically document the presence of additional abnormalities associated with these clefts. In this systematic review, we analyzed reports of Tessier clefts accompanied by cardiovascular anomalies, as one of the commonly encountered anomalies. We systematically searched PubMed (MEDLINE), Scopus, Web of Science, Science Direct, and Google Scholar. We selected and included case reports, case series, and case reviews on patients with Tessier cleft and cardiovascular anomalies. The critical appraisal of the included studies was performed by two independent investigators using the Consensus-based Clinical Case Reporting Guideline Development (CARE) checklist. Overall, 20 reports (18 case reports and 2 case series) were eligible for inclusion in this review. Tessier clefts 3 and 30 were the most commonly observed. In addition, the most prevalent cardiovascular anomalies consisted of the ventricular septal defect (VSD), double-outlet right ventricle, and atrial septal defect (ASD). Most of the patients received cosmetic and cardiovascular surgeries. However, some were not proper candidates for cardiovascular surgery because of their unstable condition and therefore did not survive. Conclusion: Regardless of the focus placed on the cleft and subsequent plastic surgery procedures in these cases, it is important to prioritize other abnormalities that may be associated with mortality. A complete cardiovascular system and associated disorders assessment should be performed before facial cosmetic surgeries. What is Known: • Tessier clefts are congenital defects in the soft tissues and bones of the face and like many other congenital defects, they are accompanied by defects in other parts of the body. • In the current literature, the emphasis is on clefts and the cosmetic issues rather than the coinciding defects, particularly cardiovascular anomalies. What is New: • Review the cardiovascular anomalies that are commonly encountered in patients with Tessier clefts.
摘要：
Tessier裂隙是新生儿面部结构的骨骼和软组织异常。它们可以分为综合征性和非综合征性裂隙，这可以归因于胎儿发育中断和基因突变，分别。这些裂隙的报告病例通常证明存在与这些裂隙相关的其他异常。在这次系统审查中，我们分析了Tessier裂隙伴有心血管异常的报告，作为经常遇到的异常情况之一。我们系统地搜索了PubMed(MEDLINE)，Scopus,WebofScience,科学直接，谷歌学者。我们选择并纳入病例报告，案例系列,以及Tessier裂隙和心血管异常患者的病例回顾。由两名独立研究人员使用基于共识的临床病例报告指南开发（CARE）清单对纳入的研究进行了严格评估。总的来说,20份报告（18份病例报告和2份病例系列报告）符合纳入本综述的条件。最常见的是Tessier裂隙3和30。此外,最常见的心血管异常包括室间隔缺损（VSD），右心室双出口,和房间隔缺损（ASD）。大多数患者接受了美容和心血管手术。然而,有些人由于病情不稳定而不适合心血管手术，因此无法生存。结论：在这些情况下，无论将重点放在裂口和随后的整形手术上，重要的是优先考虑其他可能与死亡率相关的异常.在面部美容手术之前，应进行完整的心血管系统和相关疾病评估。已知内容：•Tessier裂隙是面部软组织和骨骼的先天性缺陷，与许多其他先天性缺陷一样，它们伴随着身体其他部位的缺陷。•在当前的文献中，重点是裂缝和外观问题，而不是重合的缺陷，尤其是心血管异常.新增内容：•回顾Tessier裂隙患者常见的心血管异常。
