Abstract：
To investigate the relationship between fluoride exposure and Osteochondroma (OC) prevalence, a cross-sectional study was conducted in drinking water endemic fluorosis areas of Heilongjiang Province, China. Our study first reported that the prevalence of OC was 2.3% in drinking water endemic fluorosis areas of Heilongjiang Province, China, and no difference in gender. Logistic regression analysis found that compared to 1st quartile participants, the prevalence of OC was 73% lower in the 2nd quartile participants of WF (Water fluoride), and 3.4 times higher among the 2nd quartile UF (Urinary fluoride) participants. Our study suggests that 0.259-0.420 mg/L of WF may be considered an appropriate level for reducing OC prevalence, while UF (≥0.750 mg/L) could slightly increase the prevalence of OC. In summary, the link between fluoride and OC prevalence is complicated and needs to be further investigated in a cohort population.
摘要：
探讨氟暴露与骨软骨瘤(OC)患病率的关系。在黑龙江省饮用水地方性氟中毒地区进行了横断面研究，中国。我们的研究首次报道了黑龙江省饮用水地方性氟中毒地区OC的患病率为2.3％，中国,没有性别差异。Logistic回归分析发现，与第一四分位数参与者相比，在WF（水氟化物）的第2四分位数参与者中，OC的患病率降低了73％，在第二四分位数UF（尿氟化物）参与者中高出3.4倍。我们的研究表明，0.259-0.420mg/L的WF可能被认为是降低OC患病率的适当水平。UF(≥0.750mg/L)可略微增加OC的患病率。总之,氟化物和OC患病率之间的联系很复杂,需要在队列人群中进一步研究.
