METHODS: All consecutive GC procedures performed between July 2011 and March 2018 at our hospital were analysed. COBE Spectra was used until 5 February 2016, and Spectra Optia was used afterwards. HES was not used.
RESULTS: Twenty-six GC procedures were performed, including 18 performed using COBE Spectra and 8 using Spectra Optia. When Spectra Optia was used, >1 × 1010 neutrophils were collected from seven of the eight (88%) procedures. Although there was no significant difference in the granulocyte yield between COBE Spectra-based and Spectra Optia-based GC procedures, the collection efficiency of Spectra Optia was significantly higher than that of COBE Spectra (p = 0.021). Furthermore, the granulocyte yields of Spectra Optia-based GC tended to be more strongly correlated with the peripheral blood neutrophil count on the day of apheresis than those of COBE Spectra-based GC.
CONCLUSIONS: Our results suggest that Spectra Optia achieves greater GC efficiency than COBE Spectra, even without HES. GTX may be a therapeutic option for severe neutropenia, even in places where HES is not available.
方法:分析2011年7月至2018年3月在我院进行的所有连续GC手术。使用COBE光谱直到2016年2月5日,之后使用光谱。未使用HES。
结果:进行了26个GC程序,包括使用COBE光谱进行的18和使用光谱光学进行的8。当使用SpectraOptia时,从八个程序中的七个(88%)收集>1×1010个嗜中性粒细胞。尽管基于COBE光谱和基于光谱的GC程序之间的粒细胞产量没有显着差异,光谱的收集效率明显高于COBE光谱(p=0.021)。此外,与基于COBE光谱的GC相比,基于光谱的GC在单采当天的粒细胞产量与外周血中性粒细胞计数的相关性更强。
结论:我们的结果表明,光谱光学比COBE光谱具有更大的GC效率,即使没有他。GTX可能是严重中性粒细胞减少症的治疗选择,即使在HES不可用的地方。