Abstract：
Resveratrol, a natural organic polyhydroxyphenolic compound, has gained significant attention in the last years given its potential health benefits, including antioxidant, anti-cancer, and anti-inflammatory properties. It can be directly extracted from plants, vegetables, and related products and waste resources, but also chemically/enzymatically/microbially synthesized. However, certain process strategies have some limitations, such as high costs, reduced yield or high energy demand, thus implying significant environmental loads. In this context, the search for more sustainable and circular process schemes is key to the integration of resveratrol into the market value chain of the food, cosmetic and pharmaceutical sectors. The extraction of resveratrol has traditionally been based on conventional methods such as solvent extraction, but advanced green extraction techniques offer more efficient and environmentally friendly alternatives. This review analyses both conventional and green alternative extraction technologies, as well as its bioproduction through microbial fermentation, in terms of production capacity, yield, purity and sustainability. It also presents alternative biorefinery models based on resveratrol bioproduction using by-products and waste streams as resources, specifically considering wine residues, peanut shells and wood bark as input resources, and also following a circular approach. This critical review provides some insight into the opportunities that resveratrol offers for promoting sustainable development and circularity in the related market value chains, and thus provides some criteria for decision making for biorefinery models in which resveratrol is one of the targeted high value-added products. It also identifies the future challenges to promote the inclusion of resveratrol in value chains, with the scale-up of green technologies and its demonstrated economic feasibility being the most prominent.
摘要：
白藜芦醇,一种天然有机多羟基酚类化合物，鉴于其潜在的健康益处，在过去几年中获得了广泛的关注，包括抗氧化剂，抗癌，和抗炎特性。它可以直接从植物中提取，蔬菜,以及相关产品和废物资源，而且化学/酶/微生物合成。然而,某些过程策略有一些局限性，比如高成本，产量降低或能源需求高，因此意味着巨大的环境负荷。在这种情况下，寻找更可持续和循环的流程计划是将白藜芦醇融入食品市场价值链的关键，化妆品和制药行业。白藜芦醇的提取传统上基于常规方法，例如溶剂萃取，但是先进的绿色提取技术提供了更高效和环保的替代方案。这篇综述分析了传统和绿色替代提取技术，以及通过微生物发酵的生物生产，在生产能力方面,产量，纯度和可持续性。它还提出了基于白藜芦醇生物生产的替代生物炼制模型，使用副产品和废物流作为资源，特别是考虑到葡萄酒残留物，花生壳和树皮作为投入资源，也遵循循环的方法。这一关键审查提供了一些洞察白藜芦醇为促进相关市场价值链的可持续发展和循环提供的机会，因此为生物炼制模型的决策提供了一些标准，其中白藜芦醇是目标高附加值产品之一。它还确定了促进将白藜芦醇纳入价值链的未来挑战，绿色技术的扩大及其经证明的经济可行性最为突出。
