METHODS: We retrospectively reviewed the database from 1978 to 2018 and enrolled 3,655 consecutive patients with CRC. We investigated the clinicopathological factors of patients with CRC with and without a family history. After propensity score matching, we performed a survival analysis of patients with CRC with and without a family history.
RESULTS: Patients with CRC with a family history of CRC had a young onset (63.2 and 65.9; p<0.001), were more likely to be female (54.3% and 49.7%; p=0.042), had less symptomatic disease (76.9% and 80.8%; p=0.008), were more likely to have right-sided colon cancer (27.5% and 26.1%), and had less distant metastases (11.3% and 14.9%; p=0.023) and multiple CRCs (10.2% and 7.8%) compared with those without a family history of CRC. Prior to propensity score matching, CRC-specific survival analysis showed that a family history of CRC was a good prognostic factor (p=0.022). After propensity score matching, survival curves overlapped between the two groups.
CONCLUSIONS: Patients with CRC with a family history of CRC had specific clinicopathological features including younger onset, female sex, proximal colon location, fewer symptoms, smaller number of distant metastases, likelihood of multiple diseases, and earlier cancer stage. Family history of CRC in patients with CRC was not a prognostic factor.
方法:我们回顾性回顾了1978年至2018年的数据库,纳入了3,655例连续的CRC患者。我们调查了有和没有家族史的CRC患者的临床病理因素。在倾向得分匹配后,我们对有和无家族史的CRC患者进行了生存分析.
结果:有CRC家族史的CRC患者发病年轻(63.2和65.9;p<0.001),更有可能是女性(54.3%和49.7%;p=0.042),症状性疾病较少(76.9%和80.8%;p=0.008),更有可能患有右侧结肠癌(27.5%和26.1%),与没有CRC家族史的患者相比,远处转移较少(11.3%和14.9%;p=0.023)和多个CRC(10.2%和7.8%)。在倾向得分匹配之前,CRC特异性生存分析显示,CRC家族史是一个良好的预后因素(p=0.022)。在倾向得分匹配后,两组生存曲线重叠.
结论:有CRC家族史的CRC患者具有特定的临床病理特征,包括发病年龄较小,女性性别,近端结肠位置,症状较少,远处转移的数量较少,多种疾病的可能性,更早的癌症阶段。CRC患者的CRC家族史不是预后因素。