PDF(Pubmed)
Abstract：
MicroRNAs (miRNAs) are conserved, short, non-coding RNAs that play a crucial role in the post-transcriptional regulation of gene expression. They have been implicated in the pathogenesis of cancer and neurological, cardiovascular, and autoimmune diseases. Several recent studies have suggested that miRNAs are key players in regulating the differentiation, maturation, and activation of immune cells, thereby influencing the host immune response to infection. The resultant upregulation or downregulation of miRNAs from infection influences the protein expression of genes responsible for the immune response and can determine the risk of disease progression. Recently, miRNAs have been explored as diagnostic biomarkers and therapeutic targets in various infectious diseases. This review summarizes our current understanding of the role of miRNAs during viral, fungal, bacterial, and parasitic infections from a clinical perspective, including critical functional mechanisms and implications for their potential use as biomarkers and therapeutic targets.
摘要：
总结微小RNA（miRNA）是保守的，短,在基因表达的转录后调控中起关键作用的非编码RNA。它们与癌症和神经系统的发病机理有关，心血管,和自身免疫性疾病。最近的几项研究表明，miRNA是调节分化的关键参与者，成熟,和免疫细胞的激活，从而影响宿主对感染的免疫反应。由此产生的来自感染的miRNA的上调或下调影响负责免疫应答的基因的蛋白质表达,并且可以确定疾病进展的风险。最近,miRNA已被探索作为各种感染性疾病的诊断生物标志物和治疗靶标。这篇综述总结了我们目前对miRNA在病毒中的作用的理解。真菌,细菌,从临床角度来看，寄生虫感染，包括关键的功能机制及其作为生物标志物和治疗靶标的潜在用途。
