UNASSIGNED: A case-control study was conducted in Tunisia from February 2019 to November 2021, 160 de novo CLL patients and 160 healthy volunteers matched in age and gender were involved. DNA was extracted from peripheral blood mononuclear cells and the rs1042522 was analyzed using PCR-RFLP.
UNASSIGNED: Pro variant was associated with higher susceptibility to CLL than Arg variant (p= 0.023). A significant association was found between Pro variant and prognostic classification of Binet stage C (p= 0.001), low hemoglobin level (p= 0.003) and low platelet count (p= 0.016).
UNASSIGNED: We suggest that Pro variant may increase the risk of developing CLL in our population and could be associated with the severity of the disease.
于2019年2月至2021年11月在突尼斯进行了一项病例对照研究,涉及160名新生CLL患者和160名年龄和性别匹配的健康志愿者。从外周血单核细胞中提取DNA,并使用PCR-RFLP分析rs1042522。
■Pro变异体对CLL的易感性高于Arg变异体(p=0.023)。发现Pro变异与BinetC期的预后分类之间存在显着关联(p=0.001),低血红蛋白水平(p=0.003)和低血小板计数(p=0.016)。
■我们建议Pro变异可能会增加我们人群中发生CLL的风险,并且可能与疾病的严重程度有关。