Abstract：
BACKGROUND: Previous reports have shown a potential causal impact of vasectomy on prostate cancer (PCa). The objective of this study was to investigate the association between vasectomy and PCa, while evaluating the influence of confounding factors such as prostate-specific antigen (PSA) screening and body mass index (BMI).
METHODS: Mendelian randomization (MR) study using summary statistics from genome-wide associations of vasectomy (462,933 European ancestry), ever had PSA test (200,410 European ancestry), time since last PSA test (46,104 European ancestry), BMI (152,893 European males) and PCa (79,148 cases, 61,106 controls, European ancestry). This study was conducted using summary statistic data from large, previously described cohorts. Data analyses were conducted from November 2022 to June 2023.
RESULTS: Genetic liability to vasectomy was not associated with PCa (OR = 0.07, 95% CI: 2.95 × 10-3 , 1.54, p = 0.09). Genetic liability to vasectomy was not associated with ever had PSA test (OR = 1.08, 95% CI: 0.49-2.39, p = 0.83) and time since last PSA test (OR = 2.49, 95% CI: 0.71-8.79, p = 0.16). After controlling for PSA test and BMI, there remains no causal relationship between vasectomy and PCa risk (OR = 5.56 × 10-4 , 95% CI: 7.29 × 10-8 , 4.24, p = 0.10). The reverse MR results showed a weak association between PCa and vasectomy patients (OR = 1.00, 95% CI: 1.0003-1.0033, p = 0.02).
CONCLUSIONS: Based on the available evidence from MR analysis, the current findings did not support vasectomy being a risk factor for PCa. Further work is required to provide additional confirmation and validation of the potential link.
METHODS: Mendelian randomization (MR) study using summary statistics from genome-wide associations of vasectomy (462,933 European ancestry), ever had PSA test (200,410 European ancestry), time since last PSA test (46,104 European ancestry), BMI (152,893 European males) and PCa (79,148 cases, 61,106 controls, European ancestry). This study was conducted using summary statistic data from large, previously described cohorts. Data analyses were conducted from November 2022 to June 2023.
RESULTS: Genetic liability to vasectomy was not associated with PCa (OR = 0.07, 95% CI: 2.95 × 10-3 , 1.54, p = 0.09). Genetic liability to vasectomy was not associated with ever had PSA test (OR = 1.08, 95% CI: 0.49-2.39, p = 0.83) and time since last PSA test (OR = 2.49, 95% CI: 0.71-8.79, p = 0.16). After controlling for PSA test and BMI, there remains no causal relationship between vasectomy and PCa risk (OR = 5.56 × 10-4 , 95% CI: 7.29 × 10-8 , 4.24, p = 0.10). The reverse MR results showed a weak association between PCa and vasectomy patients (OR = 1.00, 95% CI: 1.0003-1.0033, p = 0.02).
CONCLUSIONS: Based on the available evidence from MR analysis, the current findings did not support vasectomy being a risk factor for PCa. Further work is required to provide additional confirmation and validation of the potential link.
摘要：
背景：先前的报道显示了输精管结扎术对前列腺癌（PCa）的潜在因果影响。这项研究的目的是调查输精管结扎术和PCa之间的关系，同时评估前列腺特异性抗原（PSA）筛查和体重指数（BMI）等混杂因素的影响。
方法：孟德尔随机化（MR）研究使用全基因组输精管切除术协会的汇总统计（462,933欧洲血统），曾经进行过PSA测试（200,410欧洲血统），自上次PSA测试以来的时间（46,104欧洲血统），BMI（152,893欧洲男性）和PCa（79,148例，61,106个控件，欧洲血统）。这项研究是使用来自大型的汇总统计数据进行的，先前描述的队列。数据分析于2022年11月至2023年6月进行。
结果：输精管结扎的遗传责任与PCa无关（OR=0.07，95％CI：2.95×$\乘以$10-3，1.54,p=0.09)。输精管结扎的遗传倾向与曾经进行过PSA测试（OR=1.08，95％CI：0.49-2.39，p=0.83）和自上次PSA测试以来的时间（OR=2.49，95％CI：0.71-8.79，p=0.16）无关。在控制PSA测试和BMI后，输精管结扎术与PCa风险之间没有因果关系(OR=5.56×$乘以$10-4，95%CI：7.29×$乘以$10-8，4.24，p=0.10）。反向MR结果显示PCa和输精管切除术患者之间的相关性较弱（OR=1.00，95％CI：1.0003-1.0033，p=0.02）。
结论：根据MR分析的现有证据，目前的研究结果不支持输精管结扎术是PCa的危险因素.需要进一步的工作来提供对潜在链接的额外确认和验证。
方法：孟德尔随机化（MR）研究使用全基因组输精管切除术协会的汇总统计（462,933欧洲血统），曾经进行过PSA测试（200,410欧洲血统），自上次PSA测试以来的时间（46,104欧洲血统），BMI（152,893欧洲男性）和PCa（79,148例，61,106个控件，欧洲血统）。这项研究是使用来自大型的汇总统计数据进行的，先前描述的队列。数据分析于2022年11月至2023年6月进行。
结果：输精管结扎的遗传责任与PCa无关（OR=0.07，95％CI：2.95×$\乘以$10-3，1.54,p=0.09)。输精管结扎的遗传倾向与曾经进行过PSA测试（OR=1.08，95％CI：0.49-2.39，p=0.83）和自上次PSA测试以来的时间（OR=2.49，95％CI：0.71-8.79，p=0.16）无关。在控制PSA测试和BMI后，输精管结扎术与PCa风险之间没有因果关系(OR=5.56×$乘以$10-4，95%CI：7.29×$乘以$10-8，4.24，p=0.10）。反向MR结果显示PCa和输精管切除术患者之间的相关性较弱（OR=1.00，95％CI：1.0003-1.0033，p=0.02）。
结论：根据MR分析的现有证据，目前的研究结果不支持输精管结扎术是PCa的危险因素.需要进一步的工作来提供对潜在链接的额外确认和验证。
