PDF(Pubmed)
Abstract：
BACKGROUND: Rosai-Dorfman disease is a benign lymphatic tissue proliferative disease with slow growth and is rarely observed in the clinic. Most of these patients present clinically with enlarged lymph nodes. In patients with spinal extranodal Rosai-Dorfman disease, which is even rare than the disease of lymph nodes, patients may experience numbness and weakness in the extremities.
METHODS: We report a 32-year-old male patient with multi-segmental spinal Rosai-Dorfman disease. On admission, his left fingers had been numb for 2 months. Over a 2-month period, the limb numbness progressed from the left to the right hand. The patient underwent resection of the lesion and internal fixation of the C2-C7 spine. The postoperative outcomes were satisfied and no recurrence was observed at 1-year follow-up.
CONCLUSIONS: Spinal Rosai-Dorfman disease is a relatively rare tumor of which the pathogenesis is still unclear, and most patients have no specific clinical manifestations. Characteristic imaging findings can indicate this disease, however, a definitive diagnosis still depends on a pathological examination. Currently, total surgical resection of the tumor is a relatively effective and preferred treatment.
METHODS: We report a 32-year-old male patient with multi-segmental spinal Rosai-Dorfman disease. On admission, his left fingers had been numb for 2 months. Over a 2-month period, the limb numbness progressed from the left to the right hand. The patient underwent resection of the lesion and internal fixation of the C2-C7 spine. The postoperative outcomes were satisfied and no recurrence was observed at 1-year follow-up.
CONCLUSIONS: Spinal Rosai-Dorfman disease is a relatively rare tumor of which the pathogenesis is still unclear, and most patients have no specific clinical manifestations. Characteristic imaging findings can indicate this disease, however, a definitive diagnosis still depends on a pathological examination. Currently, total surgical resection of the tumor is a relatively effective and preferred treatment.
摘要：
背景：Rosai-Dorfman病是一种生长缓慢的良性淋巴组织增殖性疾病，在临床上很少观察到。这些患者中的大多数在临床上表现为淋巴结肿大。在脊柱结外Rosai-Dorfman病患者中，这甚至比淋巴结疾病更罕见，患者可能会出现四肢麻木和虚弱。
方法：我们报告了一名32岁男性多节段脊柱Rosai-Dorfman病患者。一入场,他的左手手指已经麻木了两个月。在两个月的时间里，肢体麻木从左手发展到右手。患者接受了C2-C7脊柱的病变切除和内固定。术后疗效满意，随访1年无复发。
结论：脊柱Rosai-Dorfman病是一种相对罕见的肿瘤，其发病机制尚不清楚。大多数患者没有特异性的临床表现。特征性影像学表现可以提示这种疾病，然而,明确的诊断仍然取决于病理检查。目前,手术切除肿瘤是一种相对有效的首选治疗方法。
方法：我们报告了一名32岁男性多节段脊柱Rosai-Dorfman病患者。一入场,他的左手手指已经麻木了两个月。在两个月的时间里，肢体麻木从左手发展到右手。患者接受了C2-C7脊柱的病变切除和内固定。术后疗效满意，随访1年无复发。
结论：脊柱Rosai-Dorfman病是一种相对罕见的肿瘤，其发病机制尚不清楚。大多数患者没有特异性的临床表现。特征性影像学表现可以提示这种疾病，然而,明确的诊断仍然取决于病理检查。目前,手术切除肿瘤是一种相对有效的首选治疗方法。
