PubMed, Embase, Cochrane Library, and Web of Science were systematically searched until May 22, 2023. Risk factors included demographic and disease-related risk factors. Odds ratios (ORs) and weighted mean differences (WMDs) were used as the effect sizes, and shown with 95% confidence intervals (CIs). Sensitivity analysis was conducted. The protocol was registered with PROSPERO (CRD42022378652).
Twenty-two studies of 13,875 subjects were included in this systematic review and meta-analysis. Increased age was associated with a higher risk of postoperative PVR (pooled WMD = 3.98, 95%CI: 0.21, 7.75, P = 0.038). Smokers had a higher risk of postoperative PVR than non-smokers (pooled OR = 5.07, 95%CI: 2.21-11.61, P<0.001). Presence of preoperative PVR was associated with a greater risk of postoperative PVR (pooled OR = 22.28, 95%CI: 2.54, 195.31, P = 0.005). Presence of vitreous hemorrhage was associated with a greater risk of postoperative PVR (pooled OR = 4.12, 95%CI: 1.62, 10.50, P = 0.003). Individuals with aphakia or pseudophakia had an increased risk of postoperative PVR in contrast to those without (pooled OR = 1.41, 95%CI: 1.02, 1.95, P = 0.040). The risk of postoperative PVR was higher among patients with macula off versus those with macula on (pooled OR = 1.85, 95%CI: 1.24, 2.74, P = 0.002). Extent of RD in patients with postoperative PVR was larger than that in patients without (pooled WMD = 0.31, 95%CI: 0.02, 0.59, P = 0.036). Patients with postoperative PVR had longer duration of RD symptoms than those without (pooled WMD = 10.36, 95%CI: 2.29, 18.43, P = 0.012).
Age, smoking, preoperative PVR, vitreous hemorrhage, aphakia or pseudophakia, macula off, extent of RD, and duration of RD symptoms were risk factors for postoperative PVR in patients undergoing RD surgery, which may help better identify high-risk patients, and provide timely interventions.
方法:PubMed,Embase,科克伦图书馆,和WebofScience进行了系统搜索,直到2023年5月22日。危险因素包括人口统计学和疾病相关危险因素。使用赔率比(OR)和加权平均差(WMD)作为效应大小,并用95%置信区间(CI)显示。进行了敏感性分析。该方案在PROSPERO(CRD42022378652)注册。
结果:本系统综述和荟萃分析包括22项13,875名受试者。年龄增加与术后PVR的风险增加相关(合并WMD=3.98,95CI:0.21,7.75,P=0.038)。吸烟者术后PVR的风险高于不吸烟者(合并OR=5.07,95CI:2.21-11.61,P<0.001)。术前PVR的存在与术后PVR的风险增加相关(合并OR=22.28,95CI:2.54,195.31,P=0.005)。玻璃体出血的存在与术后PVR的风险增加相关(合并OR=4.12,95CI:1.62,10.50,P=0.003)。与无晶状体眼或假晶状体眼患者相比,无晶状体眼患者术后PVR风险增加(合并OR=1.41,95CI:1.02,1.95,P=0.040)。黄斑脱落患者术后PVR的风险高于黄斑脱落患者(合并OR=1.85,95CI:1.24,2.74,P=0.002)。术后PVR患者的RD程度大于无PVR患者(合并WMD=0.31,95CI:0.02,0.59,P=0.036)。术后PVR患者的RD症状持续时间长于无PVR患者(合并WMD=10.36,95CI:2.29,18.43,P=0.012)。
结论:年龄,吸烟,术前PVR,玻璃体出血,无晶状体或假晶状体,黄斑脱落,RD的范围,RD症状持续时间是RD手术患者术后PVR的危险因素,这可能有助于更好地识别高风险患者,并及时提供干预措施。