Abstract：
<b>Background and Objective:</b> Chronic Lymphocytic Leukaemia (CLL) is a frequent type of leukaemia disease. This study was focused on investigating the role of prognostic indicators, such as CD180 and MD-1 for Chronic Lymphocytic Leukaemia (CLL) pathogenesis because they involve cell signalling and proliferation. <b>Materials and Methods:</b> A total of 12 normal controls and 52 patients were taken to determine the expressions of CD180 and MD-1 with different variations in comparison with the IgVH (Immunoglobulin Heavy Chain variable region gene) mutational status, FISH (fluorescence <i>in situ</i> hybridization) and Rai staging. <b>Results:</b> The quantitative data findings were evident that CD180 and MD-1 expressions showed insignificant differences among CLL patients at the protein level based on SPSS results. On the contrary, they resulted in significant differences for subgroups of established biomarkers like Rai staging (stages 0, I, II and III), FISH (13q and non-13q deletions) and IgVH (mutated and unmutated). <b>Conclusion:</b> The CD180 and MD-1 have been used as prognostic indicators to evaluate the outcomes relevant to the cell cycle and survival rate of CLL cells.
摘要：
<b>背景和目标：</b>慢性淋巴细胞白血病（CLL）是一种常见的白血病疾病。这项研究的重点是调查预后指标的作用，例如CD180和MD-1用于慢性淋巴细胞白血病（CLL）的发病机理，因为它们涉及细胞信号传导和增殖。＆amp;lt;b＆amp;gt;材料和方法：＆amp;lt;/b＆amp;gt;共12名正常对照和52名患者，与IgVH（免疫球蛋白重链可变区基因）突变状态相比，确定CD180和MD-1的表达具有不同变异，FISH（荧光＆amp;lt;i＆amp;gt;原位＆amp;lt;/i＆amp;gt;杂交）和Rai分期。＆amp;lt;b＆amp;gt;结果：＆amp;lt;/b＆amp;gt;定量数据发现很明显，根据SPSS结果，CD180和MD-1表达在CLL患者的蛋白质水平上无明显差异。相反,它们导致已建立的生物标志物亚组的显着差异，如Rai分期(阶段0，I，II和III），FISH(13q和非13q缺失)和IgVH(突变和未突变)。结论：CD180和MD-1已被用作预后指标，以评估与CLL细胞的细胞周期和存活率相关的结果。
