PDF(Pubmed)
Abstract：
Previous studies indicated that laser acupuncture (LA) may effectively treat various medical conditions. However, brain responses associated with LA intervention have not been fully investigated. This study is focused on the effect of LA with different energy density (ED) in brain using resting-state functional magnetic resonance imaging (fMRI). We hypothesized that different ED would elicit various brain responses. We enrolled healthy adults participants and selected bilateral PC6 (Neiguan) as the intervention points. LA was applied, respectively, with ED of 0, 7.96, or 23.87 J/cm2. Two 500-s resting-state fMRI scans were acquired before and after intervention, respectively. The functional connectivity (FC) was calculated between autonomic nerve system-regulation associated brainstem structures and other brain regions. Compared to other dosages, the FC between rostral ventrolateral medulla and orbitofrontal cortex has more enhanced; the FC between caudal ventrolateral medulla, nucleus of the solitary tract/nucleus ambiguus, and dorsal motor nucleus of the vagus and somatosensory area has more weakened when ED was 23.87 J/cm2. Different dosages of LA have demonstrated varied regions of FC changes between regions of interest and other brain areas, which indicated that variations in EDs might influence the clinical efficacy and subsequent impacts through distinct neural pathways within the brain.
摘要：
先前的研究表明，激光针灸（LA）可以有效地治疗各种疾病。然而,与LA干预相关的大脑反应尚未得到充分研究.本研究的重点是使用静息态功能磁共振成像（fMRI）研究不同能量密度（ED）的LA在大脑中的作用。我们假设不同的ED会引起不同的大脑反应。我们招募健康成人参与者，并选择双侧PC6（内关）作为干预点。洛杉矶被应用，分别,ED为0、7.96或23.87J/cm2。在干预前后进行了两次500秒的静息状态功能磁共振成像扫描，分别。计算自主神经调节相关脑干结构和其他大脑区域之间的功能连接（FC）。与其他剂量相比，延髓腹外侧和眶额皮质之间的FC增强；延髓腹外侧之间的FC增强，孤束核/模糊核，当ED为23.87J/cm2时，迷走神经和体感区的背侧运动核减弱。不同剂量的LA已经证明了感兴趣区域和其他大脑区域之间的不同区域的FC变化。这表明ED的变化可能会通过大脑内不同的神经通路影响临床疗效和后续影响。
