PDF(Pubmed)
Abstract：
UNASSIGNED: Previous studies have shown that malnutrition before hematopoietic stem cell transplantation (HSCT) is associated with poor patient prognoses. There is inconsistency among studies on which nutritional status screening tool is appropriate for malnutrition diagnosis before allo-HSCT. The present study aimed to compare nutritional screening tools in patients with leukemia before allo-HSCT.
UNASSIGNED: An observational, cross-sectional, and single-center study was conducted in Tehran, Iran. One hundred four adults allo-HSCT candidates aged 18-55 years with leukemia were selected sequentially. Malnutrition assessment was done using three tools, the Global Leadership Initiative on Malnutrition (GLIM), nutritional risk screening 2002 (NRS-2002) and European Society for Clinical Nutrition and Metabolism (ESPEN) criteria. The agreement between malnutrition assessment tools was evaluated with Cohen\'s kappa.
UNASSIGNED: The agreement between GLIM and NRS-2002 was perfect (κ = 0.817, p < 0.001), while the agreement between GLIM and ESPEN was fair (κ = 0.362, p < 0.001). The agreement between NRS-2002 and ESPEN was fair (κ = 0.262, p < 0.001). We also found a moderate agreement for all tools (κ = 0.489, p < 0.001).
UNASSIGNED: NRS-2002 is an accepted tool for screening malnutrition in hospitalized patients. In the current study, the GLIM criterion perfectly agreed with the NRS-2002. Further studies in the HSCT setting are needed to introduce a valid tool.
UNASSIGNED: An observational, cross-sectional, and single-center study was conducted in Tehran, Iran. One hundred four adults allo-HSCT candidates aged 18-55 years with leukemia were selected sequentially. Malnutrition assessment was done using three tools, the Global Leadership Initiative on Malnutrition (GLIM), nutritional risk screening 2002 (NRS-2002) and European Society for Clinical Nutrition and Metabolism (ESPEN) criteria. The agreement between malnutrition assessment tools was evaluated with Cohen\'s kappa.
UNASSIGNED: The agreement between GLIM and NRS-2002 was perfect (κ = 0.817, p < 0.001), while the agreement between GLIM and ESPEN was fair (κ = 0.362, p < 0.001). The agreement between NRS-2002 and ESPEN was fair (κ = 0.262, p < 0.001). We also found a moderate agreement for all tools (κ = 0.489, p < 0.001).
UNASSIGNED: NRS-2002 is an accepted tool for screening malnutrition in hospitalized patients. In the current study, the GLIM criterion perfectly agreed with the NRS-2002. Further studies in the HSCT setting are needed to introduce a valid tool.
摘要：
■先前的研究表明，造血干细胞移植（HSCT）前的营养不良与患者预后不良有关。关于营养状况筛查工具适用于allo-HSCT前营养不良诊断的研究之间存在不一致。本研究旨在比较白血病患者在allo-HSCT之前的营养筛查工具。
■观测，横截面,单中心研究是在德黑兰进行的，伊朗。依次选择104名年龄在18-55岁的患有白血病的成人allo-HSCT候选人。使用三种工具进行营养不良评估，全球营养不良领导力倡议(GLIM)，营养风险筛查2002（NRS-2002）和欧洲临床营养与代谢学会（ESPEN）标准。使用Cohen的kappa评估了营养不良评估工具之间的一致性。
■GLIM和NRS-2002之间的协议是完美的（κ=0.817，p<0.001），而GLIM和ESPEN之间的一致性是公平的(κ=0.362，p<0.001)。NRS-2002和ESPEN之间的协议是公平的（κ=0.262，p<0.001）。我们还发现所有工具都有适度的一致性(κ=0.489，p<0.001)。
■NRS-2002是用于筛查住院患者营养不良的公认工具。在目前的研究中,GLIM标准与NRS-2002完全一致。需要在HSCT设置中进行进一步的研究以引入有效的工具。
■观测，横截面,单中心研究是在德黑兰进行的，伊朗。依次选择104名年龄在18-55岁的患有白血病的成人allo-HSCT候选人。使用三种工具进行营养不良评估，全球营养不良领导力倡议(GLIM)，营养风险筛查2002（NRS-2002）和欧洲临床营养与代谢学会（ESPEN）标准。使用Cohen的kappa评估了营养不良评估工具之间的一致性。
■GLIM和NRS-2002之间的协议是完美的（κ=0.817，p<0.001），而GLIM和ESPEN之间的一致性是公平的(κ=0.362，p<0.001)。NRS-2002和ESPEN之间的协议是公平的（κ=0.262，p<0.001）。我们还发现所有工具都有适度的一致性(κ=0.489，p<0.001)。
■NRS-2002是用于筛查住院患者营养不良的公认工具。在目前的研究中,GLIM标准与NRS-2002完全一致。需要在HSCT设置中进行进一步的研究以引入有效的工具。
