Abstract：
Inflammation is a protective response of the body potentially caused by microbial, viral, or fungal infections, tissue damage, or even autoimmune reactions. The cardinal signs of inflammation are consequences of immunological, biochemical, and physiological changes that trigger the release of pro-inflammatory chemical mediators at the local of the injured site thus, increasing blood flow, vascular permeability, and leukocyte recruitment. The aim of this study is to give an overview of the inflammatory process, focusing on chemical mediators. The literature review was based on a search of journals published between the years 2009 and 2023, regarding the role of major chemical mediators in the inflammatory process and current studies in pathogenesis, diagnosis, and therapy. Some of the recent contributions in the study of inflammatory pathologies and their mediators, including cytokines and chemokines, the kinin system, free radicals, nitric oxide, histamine, cell adhesion molecules, leukotrienes, prostaglandins and the complement system and their role in human health and chronic diseases.
摘要：
炎症是一种可能由微生物引起的机体的保护性反应，病毒，或真菌感染，组织损伤,甚至自身免疫反应。炎症的主要症状是免疫学的后果，生物化学，以及在损伤部位局部引发促炎化学介质释放的生理变化，增加血流量，血管通透性,和白细胞募集。这项研究的目的是对炎症过程进行概述，专注于化学介质。文献综述是基于对2009年至2023年之间发表的期刊的搜索，关于主要化学介质在炎症过程中的作用以及目前在发病机理中的研究。诊断,和治疗。炎症病理及其介质研究中的一些最新贡献，包括细胞因子和趋化因子,Kinin系统,自由基,一氧化氮,组胺,细胞粘附分子，白三烯,前列腺素和补体系统及其在人类健康和慢性疾病中的作用。
