Abstract：
UNASSIGNED: Persistent dyspnea is frequent in post-COVID patients, even in the absence of pulmonary embolism (PE). In this scenario, the role of lung perfusion scintigraphy is unclear. The present study correlated scintigraphy-based semiquantitative perfusion parameters with chest high-resolution computed tomography (hrCT) volumetric indexes and clinical data in post-COVID patients with persistent dyspnea.
UNASSIGNED: Sixty patients (30 post-COVID and 30 not previously affected by COVID-19) with persistent dyspnea submitted to lung perfusion scintigraphy and hrCT were retrospectively recruited. Perfusion rates of the pulmonary fields and hrCT-based normalized inflated, emphysematous, infiltrated, collapsed, and vascular lung volumes were calculated. Inflammatory and coagulation biomarkers were collected. PE at imaging was an exclusion criterion.
UNASSIGNED: Compared to controls, reduced perfusion rates of the lower pulmonary fields and higher perfusion rates of the middle ones were observed in post-COVID patients, while hrCT findings were superimposable between the two groups. Perfusion rates of lower pulmonary fields were significantly associated only with abnormal lung volumes at hrCT.
UNASSIGNED: In post-COVID dyspnea without PE, lung perfusion scintigraphy may reveal a pulmonary involvement not detectable by hrCT. Post-COVID patients may show decreased perfusion rates of lower pulmonary fields in the presence of normal vascular density and markers of inflammation/coagulation.
UNASSIGNED: Sixty patients (30 post-COVID and 30 not previously affected by COVID-19) with persistent dyspnea submitted to lung perfusion scintigraphy and hrCT were retrospectively recruited. Perfusion rates of the pulmonary fields and hrCT-based normalized inflated, emphysematous, infiltrated, collapsed, and vascular lung volumes were calculated. Inflammatory and coagulation biomarkers were collected. PE at imaging was an exclusion criterion.
UNASSIGNED: Compared to controls, reduced perfusion rates of the lower pulmonary fields and higher perfusion rates of the middle ones were observed in post-COVID patients, while hrCT findings were superimposable between the two groups. Perfusion rates of lower pulmonary fields were significantly associated only with abnormal lung volumes at hrCT.
UNASSIGNED: In post-COVID dyspnea without PE, lung perfusion scintigraphy may reveal a pulmonary involvement not detectable by hrCT. Post-COVID patients may show decreased perfusion rates of lower pulmonary fields in the presence of normal vascular density and markers of inflammation/coagulation.
摘要：
■回顾性招募了60例持续呼吸困难并接受肺灌注闪烁显像和hrCT检查的患者（30例感染COVID-19后，30例以前未受COVID-19影响）。肺野的灌注率和基于hrCT的归一化膨胀，气肿,渗透,崩溃,并计算血管肺容积。收集炎症和凝血生物标志物。成像时的PE是排除标准。
■与对照组相比，在COVID后患者中观察到下肺野的灌注率降低，而中间肺野的灌注率更高，而hrCT结果在两组之间是重叠的。下肺野的灌注率仅与hrCT的异常肺体积显着相关。
■在没有PE的COVID后呼吸困难中，肺灌注闪烁显像可能显示hrCT无法检测到的肺部受累。在正常血管密度和炎症/凝血标志物存在的情况下，COVID后患者可能显示下肺野的灌注率降低。
■与对照组相比，在COVID后患者中观察到下肺野的灌注率降低，而中间肺野的灌注率更高，而hrCT结果在两组之间是重叠的。下肺野的灌注率仅与hrCT的异常肺体积显着相关。
■在没有PE的COVID后呼吸困难中，肺灌注闪烁显像可能显示hrCT无法检测到的肺部受累。在正常血管密度和炎症/凝血标志物存在的情况下，COVID后患者可能显示下肺野的灌注率降低。
