PDF(Pubmed)
Abstract：
Cervical cancer, a major health concern among women worldwide, is closely linked to human papillomavirus (HPV) infection. This study explores the evolving landscape of HPV molecular epidemiology in Taiwan over a decade (2010-2020), where prophylactic HPV vaccination has been implemented since 2007. Analyzing data from 40,561 vaginal swab samples, with 42.0% testing positive for HPV, we reveal shifting trends in HPV genotype distribution and infection patterns. The 12 high-risk genotypes, in order of decreasing percentage, were HPV 52, 58, 16, 18, 51, 56, 39, 59, 33, 31, 45, and 35. The predominant genotypes were HPV 52, 58, and 16, accounting for over 70% of cases annually. The proportions of high-risk and non-high-risk HPV infections varied across age groups. High-risk infections predominated in sexually active individuals aged 30-50 and were mixed-type infections. The composition of high-risk HPV genotypes was generally stable over time; however, HPV31, 33, 39, and 51 significantly decreased over the decade. Of the strains, HPV31 and 33 are shielded by the nonavalent HPV vaccine. However, no reduction was noted for the other seven genotypes. This study offers valuable insights into the post-vaccine HPV epidemiology. Future investigations should delve into HPV vaccines\' effects and their implications for cervical cancer prevention strategies. These findings underscore the need for continued surveillance and research to guide effective public health interventions targeting HPV-associated diseases.
摘要：
宫颈癌,全世界妇女的主要健康问题，与人乳头瘤病毒（HPV）感染密切相关。这项研究探讨了台湾十年来（2010-2020）HPV分子流行病学的演变格局，自2007年以来一直实施预防性HPV疫苗接种。分析40,561个阴道拭子样本的数据，42.0％的HPV检测呈阳性，我们揭示了HPV基因型分布和感染模式的变化趋势.12个高危基因型,按照百分比递减的顺序，HPV52、58、16、18、51、56、39、59、33、31、45和35。主要基因型是HPV52、58和16，每年占病例的70％以上。高危和非高危HPV感染的比例因年龄组而异。高危感染在30-50岁的性活跃个体中占主导地位，为混合型感染。随着时间的推移，高危型HPV基因型的组成通常是稳定的；然而，HPV31、33、39和51在过去十年中显著下降。在菌株中，HPV31和33被非价HPV疫苗屏蔽。然而,其他7种基因型没有减少.这项研究为疫苗后HPV流行病学提供了有价值的见解。未来的研究应深入研究HPV疫苗的作用及其对宫颈癌预防策略的影响。这些发现强调了持续监测和研究的必要性，以指导针对HPV相关疾病的有效公共卫生干预措施。
