PDF(Pubmed)
Abstract：
The aim of this study was to analyze the link between periodontal microbiota and obesity in humans. We conducted a cohort study including 45 subjects with periodontitis divided into two groups: normo-weighted subjects with a body mass index (BMI) between 20 and 25 kg/m2 (n = 34) and obese subjects with a BMI > 30 kg/m2 (n = 11). Our results showed that obesity was associated with significantly more severe gingival inflammation according to Periodontal Inflamed Surface Area (PISA index). Periodontal microbiota taxonomic analysis showed that the obese (OB) subjects with periodontitis were characterized by a specific signature of subgingival microbiota with an increase in Gram-positive bacteria in periodontal pockets, associated with a decrease in microbiota diversity compared to that of normo-weighted subjects with periodontitis. Finally, periodontal treatment response was less effective in OB subjects with persisting periodontal inflammation, reflecting a still unstable periodontal condition and a risk of recurrence. To our knowledge, this study is the first exploring both salivary and subgingival microbiota of OB subjects. Considering that OB subjects are at higher periodontal risk, this could lead to more personalized preventive or therapeutic strategies for obese patients regarding periodontitis through the specific management of oral microbiota of obese patients.
摘要：
这项研究的目的是分析人类牙周微生物群与肥胖之间的联系。我们进行了一项队列研究，包括45名牙周炎患者，分为两组：体重指数（BMI）在20至25kg/m2之间的正常体重受试者（n=34）和BMI>30kg/m2的肥胖受试者（n=11）。我们的结果表明，根据牙周发炎表面积（PISA指数），肥胖与更严重的牙龈炎症有关。牙周微生物群分类分析表明，患有牙周炎的肥胖（OB）受试者的特征是牙龈下微生物群的特定特征，牙周袋中革兰氏阳性细菌的增加，与正常体重牙周炎患者相比，与微生物群多样性减少有关。最后,牙周治疗反应是无效的OB受试者与持续牙周炎症，反映了牙周状况仍然不稳定和复发的风险。据我们所知,这项研究是首次探索OB受试者的唾液和龈下微生物群。考虑到OB受试者的牙周风险较高，这可以通过对肥胖患者口腔微生物群的具体管理,为肥胖患者提供更个性化的牙周炎预防或治疗策略.
