PDF(Pubmed)
Abstract：
Fecal microbiota transplantation (FMT) is a procedure that involves transferring fecal bacteria from a healthy donor to a patients\' intestines to restore gut-immunity homeostasis. While FMT was primarily supposed to treat gastrointestinal disorders such as inflammatory bowel disease and irritable bowel syndrome-and especially Clostridium difficile infection (currently the only used as clinical treatment)-recent research has suggested that it may also become a potential treatment for gynecological disorders, including endometriosis and polycystic ovary syndrome (PCOS). On the contrary, vaginal microbiota transplantation (VMT) is a newer and less commonly used procedure than the FMT approach, and its potential applications are still being explored. It involves direct grafting of the entire vaginal microbiota of healthy women into the vaginal tract of patients to easily rebuild the local microbiota environment, restoring vaginal eubiosis and relieving symptoms. Like FMT, VMT is thought to have potential in treating different microbiota-related conditions. In fact, many gynecological disorders, such as bacterial vaginosis and vulvovaginal candidiasis, are thought to be caused by an imbalance in the vaginal microbiota. In this review, we will summarize the development, current challenges, and future perspectives of microbiota transplant, with the aim of exploring new strategies for its employment as a promising avenue for treating a broad range of gynecological diseases.
摘要：
粪便微生物移植（FMT）是一种将粪便细菌从健康供体转移到患者肠道以恢复肠道免疫稳态的过程。虽然FMT主要用于治疗胃肠道疾病，如炎症性肠病和肠易激综合征，尤其是艰难梭菌感染（目前唯一用作临床治疗），但最近的研究表明，它也可能成为妇科疾病的潜在治疗方法。包括子宫内膜异位症和多囊卵巢综合征（PCOS）。相反,与FMT方法相比，阴道微生物群移植（VMT）是一种更新且较少使用的方法，其潜在应用仍在探索中。它涉及将健康女性的整个阴道微生物群直接移植到患者的阴道中，以轻松重建局部微生物群环境，恢复阴道优生和缓解症状。像FMT一样，VMT被认为具有治疗不同微生物群相关病症的潜力。事实上,许多妇科疾病，如细菌性阴道病和外阴阴道念珠菌病，被认为是由阴道微生物群的不平衡引起的。在这次审查中,我们将总结发展，当前的挑战,以及未来微生物移植的前景，目的是探索新策略，将其作为治疗广泛妇科疾病的有希望的途径。
