PDF(Pubmed)
Abstract：
Background: Chronic ocular graft-versus-host disease (oGVHD) is a common ocular complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT), characterized by progressive inflammation of the ocular surface and refractory dry eye. In severe cases, sterile corneal perforation can occur, which poses a significant challenge, due to the low survival rate of grafts after corneal transplantation. Case Presentation: A 47-year-old female presented to our hospital with persistent dryness, foreign body sensation, and blurred vision in her left eye. Diagnosis of graft-versus-host disease with corneal descemetocele in the left eye was made after detailed history review and thorough examination. Multi-layer amniotic membrane transplantation was performed in the affected eye, resulting in amelioration of the patient\'s symptoms. This amelioration of symptoms provided the patient with a level of comfort that permitted additional time while awaiting corneal transplantation. Conclusions: We report a successful case of multi-layer amniotic membrane transplantation for the management of corneal descemetocele following allo-HSCT.
摘要：
背景:慢性眼部移植物抗宿主病(oGVHD)是异基因造血干细胞移植(allo-HSCT)后常见的眼部并发症。以进行性眼表炎症和难治性干眼为特征。在严重的情况下,可发生无菌角膜穿孔，这构成了重大挑战，由于角膜移植后移植物的存活率低。病例介绍：一位47岁的女性因持续干燥到我们医院就诊，异物感,左眼视力模糊.在详细的历史回顾和彻底检查后，诊断出左眼角膜后上皮膨出的移植物抗宿主病。在患眼进行多层羊膜移植，从而改善患者的症状。这种症状的改善为患者提供了一定程度的舒适感，从而在等待角膜移植时允许额外的时间。结论：我们报告了多层羊膜移植治疗allo-HSCT后角膜后代囊肿的成功案例。
