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Abstract：
BACKGROUND: Hypericum species are widely acknowledged for their biological attributes, with notable attention being paid to Hypericum perforatum, commonly known as St. John\'s wort (SJW) within the Hypericum section of the Hypericaceae family. This species is among the most thoroughly investigated herbal medicines, particularly in terms of its application in the management of mild to moderate depression. SJW is used to treat depression, menopausal symptoms, attention-deficit hyperactivity disorder (ADHD), somatic symptom disorder, obsessive-compulsive disorder, and skin conditions, such as wounds and muscle pain. However, the usefulness and effectiveness of SJW for male sexual and reproductive health (SRH) are not well known.
OBJECTIVE: To assess the current evidence in the literature on the effect of SJW on male SRH.
METHODS: This narrative review followed a predetermined protocol and used MEDLINE and PubMed to identify articles published in English on the effects of SJW on male SRH. The search used various keywords, such as \"Hypericum Perforatum\", \"St. John\'s Wort\", and terms related to sexual and reproductive health issues. Articles published between the inception of the database and August 2023 were included.
RESULTS: We identified 12 articles published from 1999 to 2019, the majority of which were experimental and conducted on animals. These studies demonstrate variability in terms of design, sample size, type of SJW extract used, the dosage administered, and duration of treatment. Studies have indicated potential sexual dysfunction (SD) due to SJW, which includes reduced libido, delayed ejaculation, delayed orgasm, and erectile dysfunction. Additionally, reproductive toxicity has been suggested, as evidenced by spermicidal effects through the inhibition of sperm motility, abnormal spermatozoa, chromosomal aberrations, and DNA denaturation. Furthermore, some studies have reported potential adverse events during maternal exposure, inhibition of fertilization, and disruption of reproductive parameters.
CONCLUSIONS: Our review suggests that the safety and efficacy of SJW in the treatment of human SRH remain unclear. Further comprehensive, well-designed studies with larger samples, longer exposure periods, and specific dosages are needed to clarify SJW\'s effects of SJW. Therefore, consultation with healthcare professionals before using herbal remedies or supplements is crucial.
OBJECTIVE: To assess the current evidence in the literature on the effect of SJW on male SRH.
METHODS: This narrative review followed a predetermined protocol and used MEDLINE and PubMed to identify articles published in English on the effects of SJW on male SRH. The search used various keywords, such as \"Hypericum Perforatum\", \"St. John\'s Wort\", and terms related to sexual and reproductive health issues. Articles published between the inception of the database and August 2023 were included.
RESULTS: We identified 12 articles published from 1999 to 2019, the majority of which were experimental and conducted on animals. These studies demonstrate variability in terms of design, sample size, type of SJW extract used, the dosage administered, and duration of treatment. Studies have indicated potential sexual dysfunction (SD) due to SJW, which includes reduced libido, delayed ejaculation, delayed orgasm, and erectile dysfunction. Additionally, reproductive toxicity has been suggested, as evidenced by spermicidal effects through the inhibition of sperm motility, abnormal spermatozoa, chromosomal aberrations, and DNA denaturation. Furthermore, some studies have reported potential adverse events during maternal exposure, inhibition of fertilization, and disruption of reproductive parameters.
CONCLUSIONS: Our review suggests that the safety and efficacy of SJW in the treatment of human SRH remain unclear. Further comprehensive, well-designed studies with larger samples, longer exposure periods, and specific dosages are needed to clarify SJW\'s effects of SJW. Therefore, consultation with healthcare professionals before using herbal remedies or supplements is crucial.
摘要：
背景：金丝桃属物种因其生物学属性而被广泛认可，值得注意的是贯叶连翘，通常被称为圣约翰草（SJW）在连翘科的连翘科。这个物种是研究最彻底的草药之一，特别是在轻度至中度抑郁症的管理方面。SJW用于治疗抑郁症，更年期症状,注意缺陷多动障碍（ADHD），躯体症状障碍，强迫症,和皮肤状况，如伤口和肌肉疼痛。然而,SJW对男性性健康和生殖健康（SRH）的有用性和有效性尚不为人所知。
目的：评估文献中关于SJW对男性SRH影响的现有证据。
方法：本叙述性综述遵循了预定的方案，并使用MEDLINE和PubMed确定了以英文发表的有关SJW对男性SRH的影响的文章。搜索使用了各种关键字，如“贯叶连翘”，“圣约翰麦汁”，以及与性健康和生殖健康问题有关的术语。包括从数据库开始到2023年8月之间发表的文章。
结果：我们确定了1999年至2019年发表的12篇文章，其中大部分是在动物身上进行的实验。这些研究证明了设计方面的可变性，样本量,使用的SJW提取物的类型，给药的剂量，和治疗的持续时间。研究表明潜在的性功能障碍（SD）由于SJW，其中包括性欲降低，延迟射精,高潮延迟,和勃起功能障碍。此外,有人提出生殖毒性，通过抑制精子运动的杀精子作用证明了这一点，精子异常,染色体畸变,和DNA变性。此外，一些研究报告了母体暴露期间的潜在不良事件，抑制受精，和繁殖参数的破坏。
结论：我们的综述表明，SJW治疗人类SRH的安全性和有效性尚不清楚。进一步全面,精心设计的研究样本更大，较长的暴露时间，需要具体的剂量来阐明SJW对SJW的影响。因此,在使用草药或补充剂之前咨询医疗保健专业人员是至关重要的。
目的：评估文献中关于SJW对男性SRH影响的现有证据。
方法：本叙述性综述遵循了预定的方案，并使用MEDLINE和PubMed确定了以英文发表的有关SJW对男性SRH的影响的文章。搜索使用了各种关键字，如“贯叶连翘”，“圣约翰麦汁”，以及与性健康和生殖健康问题有关的术语。包括从数据库开始到2023年8月之间发表的文章。
结果：我们确定了1999年至2019年发表的12篇文章，其中大部分是在动物身上进行的实验。这些研究证明了设计方面的可变性，样本量,使用的SJW提取物的类型，给药的剂量，和治疗的持续时间。研究表明潜在的性功能障碍（SD）由于SJW，其中包括性欲降低，延迟射精,高潮延迟,和勃起功能障碍。此外,有人提出生殖毒性，通过抑制精子运动的杀精子作用证明了这一点，精子异常,染色体畸变,和DNA变性。此外，一些研究报告了母体暴露期间的潜在不良事件，抑制受精，和繁殖参数的破坏。
结论：我们的综述表明，SJW治疗人类SRH的安全性和有效性尚不清楚。进一步全面,精心设计的研究样本更大，较长的暴露时间，需要具体的剂量来阐明SJW对SJW的影响。因此,在使用草药或补充剂之前咨询医疗保健专业人员是至关重要的。
