PDF(Pubmed)
Abstract：
This study evaluated the effectiveness of hyaluronic acid and trehalose (HA/trehalose) eyedrops in managing dry eye disease (DED) symptoms by measuring tear stability and administering a DED questionnaire. Sixty patients were treated with either HA/trehalose eyedrops (Tear A) or carmellose sodium eyedrops (Tear B) as controls. The tear breakup time (TBUT) and non-invasive breakup time (NIBUT) were monitored, and patients completed the standard patient evaluation of eye dryness (SPEED) questionnaire. After two months of twice-daily applications, patients treated with the HA/trehalose eyedrops demonstrated significant improvements in the NIBUT (12.98 ± 3.22 s) and TBUT (12.95 ± 2.98 s), indicating increased tear stability. Moreover, they reported lower dry eye sensation (6.70 ± 4.94 SPEED score points), suggesting a reduction in DED symptoms. These findings underscore the efficacy of HA/trehalose eyedrops in improving both the objective and subjective signs of DED, with twice-daily application enhancing ocular surface conditions and reducing patient-reported symptoms.
摘要：
这项研究通过测量泪液稳定性和使用DED问卷来评估透明质酸和海藻糖（HA/海藻糖）滴眼液在治疗干眼病（DED）症状中的有效性。60例患者用HA/海藻糖滴眼液（泪液A）或羧甲基纤维素钠滴眼液（泪液B）作为对照。监测泪液破裂时间(TBUT)和非侵入性破裂时间(NIBUT),患者完成标准患者眼干评价(SPEED)问卷。经过两个月每天两次的申请，使用HA/海藻糖滴眼液治疗的患者NIBUT（12.98±3.22s）和TBUT（12.95±2.98s）显着改善，显示增加的撕裂稳定性。此外，他们报告较低的干眼感（6.70±4.94速度得分），提示DED症状减轻。这些发现强调了HA/海藻糖滴眼液在改善DED的客观和主观体征方面的功效。每天两次的应用可改善眼表状况并减少患者报告的症状。
