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Abstract：
BACKGROUND: Surgical site infection (SSI) is a frequently reported complication after ankle fracture surgery. To our knowledge, no study has been conducted on its incidence in Sweden. The present study aimed to determine the incidence of, risk factors for, and most common causative pathogen of SSI.
METHODS: Patients who underwent primary surgery for an ankle fracture between 1 September 2017 and 31 August 2019 at the Sahlgrenska University Hospital were identified. Data on potential SSI risk factors and clinical outcome (infected/non-infected) were retrieved from medical records. Cox regression analysis and descriptive statistics were used.
RESULTS: Of the 480 reviewed patients, 49 developed SSI (10.2%), of which 35 (7.3%) were superficial and 14 (2.9%) were deep. Open fractures (p < 0.001) and age (p = 0.016) were statistically significant risk factors for SSI in the univariate analysis. In the multivariable analysis, only open fracture was statistically significant (HR = 3.0; 95% C.I. = 1.3-6.9, p = 0.013). Cases of Staphylococcus aureus (S. aureus) were most common (n = 12, 24.5%). Methicillin resistance was uncommon (n = 2, 4.1%).
CONCLUSIONS: An incidence of 10.2% was established, which is comparable to international findings. Infection monitoring is an important part of tackling the global challenge of antibiotic resistance. Future prospective studies to further establish risk factors are warranted to decrease the incidence of SSI.
METHODS: Patients who underwent primary surgery for an ankle fracture between 1 September 2017 and 31 August 2019 at the Sahlgrenska University Hospital were identified. Data on potential SSI risk factors and clinical outcome (infected/non-infected) were retrieved from medical records. Cox regression analysis and descriptive statistics were used.
RESULTS: Of the 480 reviewed patients, 49 developed SSI (10.2%), of which 35 (7.3%) were superficial and 14 (2.9%) were deep. Open fractures (p < 0.001) and age (p = 0.016) were statistically significant risk factors for SSI in the univariate analysis. In the multivariable analysis, only open fracture was statistically significant (HR = 3.0; 95% C.I. = 1.3-6.9, p = 0.013). Cases of Staphylococcus aureus (S. aureus) were most common (n = 12, 24.5%). Methicillin resistance was uncommon (n = 2, 4.1%).
CONCLUSIONS: An incidence of 10.2% was established, which is comparable to international findings. Infection monitoring is an important part of tackling the global challenge of antibiotic resistance. Future prospective studies to further establish risk factors are warranted to decrease the incidence of SSI.
摘要：
背景：手术部位感染（SSI）是踝关节骨折手术后常见的并发症。据我们所知,在瑞典尚未对其发病率进行研究.本研究旨在确定发病率，的危险因素，和SSI最常见的致病病原体。
方法：确定了2017年9月1日至2019年8月31日在Sahlgrenska大学医院接受踝关节骨折初次手术的患者。从医疗记录中检索有关潜在SSI危险因素和临床结果（感染/未感染）的数据。采用Cox回归分析和描述性统计。
结果：在480名患者中，49个发展的SSI（10.2％），其中35人(7.3%)为浅层,14人(2.9%)为深层。在单因素分析中，开放性骨折（p<0.001）和年龄（p=0.016）是具有统计学意义的SSI危险因素。在多变量分析中，只有开放性骨折有统计学意义(HR=3.0;95%C.I.=1.3-6.9,p=0.013).金黄色葡萄球菌（S.金黄色葡萄球菌）最常见（n=12，24.5%）。甲氧西林耐药不常见（n=2，4.1％）。
结论：确定发生率为10.2％，这与国际调查结果相当。感染监测是应对全球抗生素耐药性挑战的重要组成部分。未来的前瞻性研究进一步确定危险因素是必要的，以降低SSI的发生率。
方法：确定了2017年9月1日至2019年8月31日在Sahlgrenska大学医院接受踝关节骨折初次手术的患者。从医疗记录中检索有关潜在SSI危险因素和临床结果（感染/未感染）的数据。采用Cox回归分析和描述性统计。
结果：在480名患者中，49个发展的SSI（10.2％），其中35人(7.3%)为浅层,14人(2.9%)为深层。在单因素分析中，开放性骨折（p<0.001）和年龄（p=0.016）是具有统计学意义的SSI危险因素。在多变量分析中，只有开放性骨折有统计学意义(HR=3.0;95%C.I.=1.3-6.9,p=0.013).金黄色葡萄球菌（S.金黄色葡萄球菌）最常见（n=12，24.5%）。甲氧西林耐药不常见（n=2，4.1％）。
结论：确定发生率为10.2％，这与国际调查结果相当。感染监测是应对全球抗生素耐药性挑战的重要组成部分。未来的前瞻性研究进一步确定危险因素是必要的，以降低SSI的发生率。
