PDF(Pubmed)
Abstract：
This longitudinal study aimed to evaluate facial growth and soft tissue changes in infants with complete unilateral cleft lip, alveolus, and palate (CUCLAP) at ages 3, 9, and 12 months. Using 3D images of 22 CUCLAP infants, average faces and distance maps for the entire face and specific regions were created. Color-coded maps highlighted more significant soft tissue changes from 3 to 9 months than from 9 to 12 months. The first interval showed substantial growth in the entire face, particularly in the forehead, eyes, lower lip, chin, and cheeks (p < 0.001), while the second interval exhibited no significant growth. This study provides insights into facial soft tissue growth in CUCLAP infants during critical developmental stages, emphasizing substantial improvements between 3 and 9 months, mainly in the chin, lower lip, and forehead. However, uneven growth occurred in the upper lip, philtrum, and nostrils throughout both intervals, with an overall decline in growth from 9 to 12 months. These findings underscore the dynamic nature of soft tissue growth in CUCLAP patients, highlighting the need to consider these patterns in treatment planning. Future research should explore the underlying factors and develop customized treatment interventions for enhanced facial aesthetics and function in this population.
摘要：
这项纵向研究旨在评估完全性单侧唇裂婴儿的面部发育和软组织变化，肺泡,和腭（CUCLAP）在年龄3，9和12个月。使用22个CUCLAP婴儿的3D图像，创建整个面部和特定区域的平均面部和距离图。颜色编码图突出显示了从3到9个月比从9到12个月更显著的软组织变化。第一个间隔显示整个面部都有很大的增长，特别是在前额，眼睛,下唇,下巴,和脸颊（p<0.001），而第二个间隔没有表现出显著的增长。这项研究提供了在关键发育阶段CUCLAP婴儿面部软组织生长的见解，强调在3到9个月之间有实质性的改善，主要在下巴，下唇,和前额。然而,不均匀的生长发生在上唇，philtrum,和鼻孔在两个间隔中，从9个月到12个月的整体增长下降。这些发现强调了CUCLAP患者软组织生长的动态性，强调在治疗计划中需要考虑这些模式。未来的研究应该探索潜在的因素，并开发定制的治疗干预措施，以增强该人群的面部美学和功能。
