PDF(Pubmed)
Abstract：
Nasal nitric oxide (nNO) is a gas synthesized by the inducible and constitutive NO synthase (NOS) enzyme in the airway cells of the nasal mucosa. Like lung nitric oxide, it is thought to be associated with airway inflammation in various respiratory diseases in children. The aim of our review was to investigate the current state of use of nNO measurement in children. A comprehensive search was conducted using the Web of Science and PubMed databases specifically targeting publications in the English language, with the following keywords: nasal NO, children, allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, primary ciliary dyskinesia (PCD), and cystic fibrosis (CF). We describe the use of nNO in pediatric allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, PCD, and CF based on the latest literature. nNO is a noninvasive, clinically applicable test for use in pediatric allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, PCD, and CF. It can be used as a complementary method in the diagnosis of these respiratory diseases and as a monitoring method for the treatment of allergic rhinitis and acute and chronic rhinosinusitis.
摘要：
鼻一氧化氮（nNO）是由鼻粘膜气道细胞中的诱导型和组成型NO合酶（NOS）酶合成的气体。像肺一氧化氮一样，它被认为与儿童各种呼吸道疾病的气道炎症有关。我们审查的目的是调查儿童使用nNO测量的现状。使用WebofScience和PubMed数据库进行了全面搜索，专门针对英文出版物，具有以下关键词：鼻NO，孩子们,过敏性鼻炎,慢性鼻-鼻窦炎,急性鼻-鼻窦炎,原发性纤毛运动障碍（PCD），囊性纤维化（CF）。我们描述了nNO在小儿过敏性鼻炎中的应用，慢性鼻-鼻窦炎,急性鼻-鼻窦炎,PCD,和CF基于最新文献。NNO是非侵入性的，用于小儿过敏性鼻炎的临床适用测试，慢性鼻-鼻窦炎,急性鼻-鼻窦炎,PCD,和CF。它可以作为诊断这些呼吸系统疾病的补充方法，也可以作为治疗过敏性鼻炎和急慢性鼻-鼻窦炎的监测方法。
