Abstract：
Bioactive compounds derived from secondary metabolism in animals have refined selectivity and potency for certain biological targets. The superfamily Dendrobatoidea is adapted to the dietary sequestration and secretion of toxic alkaloids, which play a role in several biological activities, and thus serve as a potential source for pharmacological and biotechnological applications. This article constitutes a scoping review to understand the trends in experimental research involving bioactive alkaloids derived from Dendrobatoidea based upon scientometric approaches. Forty-eight (48) publications were found in 30 journals in the period of 60 years, between 1962 and 2022. More than 23 structural classes of alkaloids were cited, with 27.63% for batrachotoxins, 13.64% for pyridinics, with an emphasis on epibatidine, 16.36% for pumiliotoxins, and 11.82% for histrionicotoxins. These tests included in vivo (54.9%), in vitro (39.4%), and in silico simulations (5.6%). Most compounds (54.8%) were isolated from skin extracts, whereas the remainder were obtained through molecular synthesis. Thirteen main biological activities were identified, including acetylcholinesterase inhibitors (27.59%), sodium channel inhibitors (12.07%), cardiac (12.07%), analgesic (8.62%), and neuromuscular effects (8.62%). The substances were cited as being of natural origin in the \"Dendrobatidae\" family, genus \"Phyllobates,\" \"Dendrobates,\" and seven species: Epipedobates tricolor, Phyllobates aurotaenia, Oophaga histrionica, Oophaga pumilio, Phyllobates terribilis, Epipedobates anthonyi, and Ameerega flavopicta. To date, only a few biological activities have been experimentally tested; hence, further studies on the bioprospecting of animal compounds and ecological approaches are needed.
摘要：
源自动物次级代谢的生物活性化合物对某些生物靶标具有精细的选择性和效力。Dendrobatoidea超家族适应于饮食隔离和分泌有毒生物碱，在几种生物活动中发挥作用，从而成为药理学和生物技术应用的潜在来源。本文构成了范围审查，以了解基于科学计量学方法的涉及来自Dendrobatoidea的生物活性生物碱的实验研究趋势。在60年的时间里，在30种期刊上发现了48种出版物，1962年至2022年。引用了超过23个生物碱的结构类别，细菌毒素为27.63%，吡啶类13.64%，强调epibatiine，短波毒素的16.36%，和11.82%的组织毒素。这些测试包括体内（54.9%），体外（39.4%），和计算机模拟（5.6%）。大多数化合物（54.8%）是从皮肤提取物中分离出来的，而其余的是通过分子合成获得的。确定了13种主要生物活性，包括乙酰胆碱酯酶抑制剂（27.59%），钠通道抑制剂（12.07%），心脏（12.07%），镇痛（8.62%），和神经肌肉效应(8.62%)。这些物质被称为“Dendrobatidae”家族的天然来源，属\“叶瓣，\"\"Dendrubates,\“和七个物种：Epipedobates三色，叶瓣aurotaenia，Oophagahistrionica,Oophagapumilio,裂叶，Epipedobates蒽酮,和阿米雷加黄皮。迄今为止,只有少数生物活性经过实验测试；因此，需要进一步研究动物化合物的生物勘探和生态方法。
