PDF(Pubmed)
Abstract：
Comparative studies of aging are a promising approach to identifying general properties of and processes leading to aging. While to date, many comparative studies of aging in animals have focused on relatively narrow species groups, methodological innovations now allow for studies that include evolutionary distant species. However, comparative studies of aging across a wide range of species that have distinct life histories introduce additional challenges in experimental design. Here, we discuss these challenges, highlight the most pressing problems that need to be solved, and provide suggestions based on current approaches to successfully carry out comparative aging studies across the animal kingdom.
摘要：
老化的比较研究是确定导致老化的一般性质和过程的有前途的方法。到目前为止，许多动物衰老的比较研究都集中在相对狭窄的物种群体上，方法创新现在允许研究，包括进化遥远的物种。然而,在具有不同生活史的各种物种中进行衰老的比较研究，给实验设计带来了额外的挑战。这里,我们讨论这些挑战，突出需要解决的最紧迫问题，并根据目前的方法提供建议，以成功地在整个动物界进行比较衰老研究。
