PDF(Pubmed)
Abstract：
BACKGROUND: Over the last 20 years, fructose has gradually emerged as a potential metabolic substrate capable of promoting the growth and progression of various cancers, including prostate cancer (PCa). The biological and molecular mechanisms that underlie the effects of fructose on cancer are beginning to be elucidated.
METHODS: This review summarizes the biological function of fructose as a potential carbon source for PCa cells and its role in the functionality of the male reproductive tract under normal conditions.
RESULTS: The most recent biological advances related to fructose transport and metabolism as well as their implications in PCa growth and progression suggest that fructose represent a potential carbon source for PCa cells. Consequently, fructose derivatives may represent efficient radiotracers for obtaining PCa images via positron emission tomography and fructose transporters/fructose-metabolizing enzymes could be utilized as potential diagnostic and/or predictive biomarkers for PCa.
CONCLUSIONS: The existing data suggest that restriction of fructose from the diet could be a useful therapeutic strategy for patients with PCa.
METHODS: This review summarizes the biological function of fructose as a potential carbon source for PCa cells and its role in the functionality of the male reproductive tract under normal conditions.
RESULTS: The most recent biological advances related to fructose transport and metabolism as well as their implications in PCa growth and progression suggest that fructose represent a potential carbon source for PCa cells. Consequently, fructose derivatives may represent efficient radiotracers for obtaining PCa images via positron emission tomography and fructose transporters/fructose-metabolizing enzymes could be utilized as potential diagnostic and/or predictive biomarkers for PCa.
CONCLUSIONS: The existing data suggest that restriction of fructose from the diet could be a useful therapeutic strategy for patients with PCa.
摘要：
背景：在过去的20年里，果糖已逐渐成为一种潜在的代谢底物，能够促进各种癌症的生长和进展，包括前列腺癌（PCa）。果糖对癌症影响的生物学和分子机制已开始阐明。
方法：这篇综述总结了果糖作为PCa细胞潜在碳源的生物学功能及其在正常条件下对男性生殖道功能的作用。
结果：与果糖转运和代谢相关的最新生物学进展及其对PCa生长和进展的影响表明，果糖是PCa细胞的潜在碳源。因此,果糖衍生物可以代表用于通过正电子发射断层扫描获得PCa图像的有效放射性示踪剂,并且果糖转运蛋白/果糖代谢酶可以用作PCa的潜在诊断和/或预测性生物标志物。
结论：现有数据表明，限制饮食中的果糖可能是PCa患者的有效治疗策略。
方法：这篇综述总结了果糖作为PCa细胞潜在碳源的生物学功能及其在正常条件下对男性生殖道功能的作用。
结果：与果糖转运和代谢相关的最新生物学进展及其对PCa生长和进展的影响表明，果糖是PCa细胞的潜在碳源。因此,果糖衍生物可以代表用于通过正电子发射断层扫描获得PCa图像的有效放射性示踪剂,并且果糖转运蛋白/果糖代谢酶可以用作PCa的潜在诊断和/或预测性生物标志物。
结论：现有数据表明，限制饮食中的果糖可能是PCa患者的有效治疗策略。
