PDF(Pubmed)
Abstract：
Cellular senescence (CS), classically considered a stable cell cycle withdrawal, is hallmarked by a progressive decrease in cell growth, differentiation, and biological activities. Senescent cells (SNCs) display a complicated senescence-associated secretory phenotype (SASP), encompassing a variety of pro-inflammatory factors that exert influence on the biology of both the cell and surrounding tissue. Among global mortality causes, cardiovascular diseases (CVDs) stand out, significantly impacting the living quality and functional abilities of patients. Recent data suggest the accumulation of SNCs in aged or diseased cardiovascular systems, suggesting their potential role in impairing cardiovascular function. CS operates as a double-edged sword: while it can stimulate the restoration of organs under physiological conditions, it can also participate in organ and tissue dysfunction and pave the way for multiple chronic diseases under pathological states. This review explores the mechanisms that underlie CS and delves into the distinctive features that characterize SNCs. Furthermore, we describe the involvement of SNCs in the progression of CVDs. Finally, the study provides a summary of emerging interventions that either promote or suppress senescence and discusses their therapeutic potential in CVDs.
摘要：
细胞衰老(CS),传统上被认为是稳定的细胞周期退出，细胞生长逐渐减少，分化,和生物活动。衰老细胞（SNCs）表现出复杂的衰老相关分泌表型（SASP），包括多种对细胞和周围组织的生物学产生影响的促炎因子。在全球死亡原因中，心血管疾病（CVD）脱颖而出，显着影响患者的生活质量和功能能力。最近的数据表明SNCs在老年或患病的心血管系统中积累，提示它们在损害心血管功能方面的潜在作用。CS是一把双刃剑：虽然它可以在生理条件下刺激器官的恢复，它还可以参与器官和组织功能障碍，为病理状态下的多种慢性疾病铺平道路。这篇综述探讨了CS的基础机制，并探讨了表征SNCs的独特特征。此外，我们描述了SNCs参与CVD的进展。最后,本研究总结了促进或抑制衰老的新兴干预措施,并讨论了它们在心血管疾病中的治疗潜力.
