PDF(Pubmed)
Abstract：
Non-alcoholic fatty liver disease (NAFLD) is a very common liver disease associated with obesity, unhealthy diet, and lack of physical exercise. Short-term aerobic or resistance exercise has been shown to result in reduced liver fat in patients with NAFLD; however, the impact of the combination of these types of exercise has received less attention. This study investigated the effect of a short-term (7 days) concurrent exercise training program performed daily on liver steatosis indices, as well as the glycemic and lipidemic profile of overweight/obese sedentary volunteers. Twenty adult patients (age: 47.3 ± 12.3 yrs, body mass index: 32.4 ± 3.4 kg/m2) with NAFLD, detected by ultrasound and hematological indices, participated in the study. Pre- and post-exercise intervention assessment included body weight (BW), waist circumference (WC), hip/waist ratio (H/W), Homeostasis Model Assessment Insulin Resistance (HOMA-IR), blood lipids, and steatosis indices. Fatty Liver Index, Lipid Accumulation Index, WC, H/W, triglycerides, and total cholesterol were improved (p < 0.05) post-exercise, while no differences (p > 0.05) were observed in BW, HOMA-IR, HDL, LDL, Hepatic Steatosis Index, and Framingham Steatosis Index compared to pre-exercise values. It is concluded that a 7-day combined exercise program can have beneficial effects on hepatic steatosis and central adiposity indices, independently of weight loss, in patients with NAFLD.
摘要：
非酒精性脂肪性肝病（NAFLD）是与肥胖相关的一种非常常见的肝病，不健康的饮食,缺乏体育锻炼。短期有氧或抗阻运动已被证明可以减少NAFLD患者的肝脏脂肪；然而，这些类型的运动组合的影响受到的关注较少。这项研究调查了每天进行的短期（7天）并发运动训练计划对肝脏脂肪变性指数的影响，以及超重/肥胖久坐志愿者的血糖和血脂特征。20名成年患者（年龄：47.3±12.3岁，体重指数：32.4±3.4kg/m2）与NAFLD，通过超声和血液学指标检测，参与研究。运动干预前后评估包括体重（BW），腰围（WC），臀围/腰围比(H/W),稳态模型评估胰岛素抵抗（HOMA-IR），血脂,和脂肪变性指数。脂肪肝指数,脂质积累指数,WC,H/W,甘油三酯，运动后总胆固醇改善（p<0.05），而BW没有观察到差异(p>0.05)，HOMA-IR,HDL,LDL,肝脏脂肪变性指数,和弗雷明汉脂肪变性指数与运动前的值相比。结论是，7天的联合运动计划可以对肝脏脂肪变性和中枢肥胖指数产生有益的影响。独立于减肥，NAFLD患者。
