PDF(Pubmed)
Abstract：
Three systemic biological systems, i.e., the nervous, the immune, and the cardiovascular systems, form a mutually responsive and forward-acting tissue network to regulate acute and chronic cardiovascular function in health and disease. Two sub-circuits within the cardiovascular system have been described, the artery brain circuit (ABC) and the heart brain circuit (HBC), forming a large cardiovascular brain circuit (CBC). Likewise, the nervous system consists of the peripheral nervous system and the central nervous system with their functional distinct sensory and effector arms. Moreover, the immune system with its constituents, i.e., the innate and the adaptive immune systems, interact with the CBC and the nervous system at multiple levels. As understanding the structure and inner workings of the CBC gains momentum, it becomes evident that further research into the CBC may lead to unprecedented classes of therapies to treat cardiovascular diseases as multiple new biologically active molecules are being discovered that likely affect cardiovascular disease progression. Here, we weigh the merits of integrating these recent observations in cardiovascular neurobiology into previous views of cardiovascular disease pathogeneses. These considerations lead us to propose the Neuroimmune Cardiovascular Circuit Hypothesis.
摘要：
三个系统生物系统，即，紧张，免疫,和心血管系统，形成一个相互反应和前瞻性的组织网络，以调节健康和疾病中的急性和慢性心血管功能。已经描述了心血管系统内的两个子回路，动脉脑回路（ABC）和心脑回路（HBC），形成大的心血管脑回路（CBC）。同样，神经系统由周围神经系统和中枢神经系统组成，它们的功能不同的感觉臂和效应臂。此外，免疫系统及其成分，即，先天和适应性免疫系统，在多个层面与CBC和神经系统相互作用。随着了解CBC的结构和内部运作获得动力，很明显，对CBC的进一步研究可能会导致前所未有的治疗心血管疾病的疗法，因为发现了多种可能影响心血管疾病进展的新生物活性分子。这里,我们权衡了将这些最近在心血管神经生物学中的观察结果与以前的心血管疾病发病机制观点相结合的优点.这些考虑导致我们提出神经免疫心血管回路假说。
