PDF(Pubmed)
Abstract：
We present the case of a 15-year-old girl, with a fifth cystic progression of an adamantinomatous craniopharyngioma after multiple surgeries and previous local radiotherapy. She had severe visual impairment, panhypopituitarism including diabetes insipidus, and several components of hypothalamic damage, including morbid obesity and severe fatigue. To prevent further late effects hampering her quality of survival, she was treated biweekly with intravenous tocilizumab, an anti-interleukin-6 agent, which stabilized the cyst for a prolonged time. Based on the biology of adamantinomatous craniopharyngioma, this immune-modulating treatment seems promising for the treatment of this cystic tumor in order to reduce surgery and delay or omit radiotherapy.
摘要：
我们介绍一个15岁女孩的案例，在多次手术和先前的局部放疗后，金刚烷虫颅咽管瘤的第五次囊性进展。她有严重的视力障碍,全垂体功能减退症包括尿崩症，和下丘脑损伤的几个组成部分，包括病态肥胖和严重疲劳。为了防止进一步的晚期影响影响她的生存质量，她每两周接受一次静脉注射托珠单抗，一种抗白细胞介素-6的药物,使囊肿稳定了很长时间.基于金刚烷虫颅咽管瘤的生物学，这种免疫调节治疗对于这种囊性肿瘤的治疗似乎很有希望，以减少手术，延迟或省略放疗。
