Abstract：
Opioid-induced hyperalgesia (OIH) is characterized by a paradoxical increase in pain sensitivity following opioid exposure. Although animal models indicate that electroacupuncture (EA) is effective against pain sensitization, there are no reports of its clinical application in OIH treatment. This case report involves an adult patient with osteomalacia complicated by multiple vertebral fragility fractures. The patient developed OIH following the use of oxycodone to treat severe disabling lower back pain that was refractory to nonsteroidal anti-inflammatory drugs. After hospitalization and treatment with low EA-frequency (2-10 Hz) sessions, the patient exhibited significant pain reduction and functional recovery after the first session, which was accompanied by steady progressive improvement as the treatment continued. This case report illustrates the clinical efficacy of EA in OIH treatment and indicates that EA, which has multiple modes of action on the neurobiology of chronic pain, has potential applications in the management of complex and difficult-to-manage conditions, such as OIH.
摘要：
阿片类药物诱导的痛觉过敏（OIH）的特征是阿片类药物暴露后疼痛敏感性的矛盾增加。虽然动物模型表明电针（EA）对疼痛敏感是有效的，目前尚无临床应用于OIH治疗的报道。该病例报告涉及一名患有骨软化症并伴有多发性椎体脆性骨折的成年患者。患者在使用羟考酮治疗严重致残的下背部疼痛后出现OIH，这种疼痛对非甾体类抗炎药无效。住院和低EA频率（2-10Hz）治疗后，患者在第一次治疗后表现出明显的疼痛减轻和功能恢复，随着治疗的继续，伴随着稳定的进行性改善。此病例报告说明了EA在OIH治疗中的临床疗效，并表明EA，它对慢性疼痛的神经生物学有多种作用模式，在复杂和难以管理的条件的管理中具有潜在的应用，比如OIH。
