PDF(Pubmed)
Abstract：
Nephrotic syndrome (NS) is a condition associated with hypercoagulability. Thromboembolic events are a well-recognized complication of NS. Venous thrombosis is well known, while arterial thrombosis, which is more severe, occurs less frequently and is mainly reported in children in the literature. The aim of this study was to understand these rare adult cases of NS associated with acute lower extremity arterial thrombosis and draw attention to them to prevent misdiagnosis and delayed treatment.
From January 2011 and October 2022, we conducted a retrospective study of patients with NS and arterial thrombosis. Their clinical manifestations, imaging characteristics, treatments and outcomes were analyzed and compared, and a literature review was performed.
Nine adults with NS and acute lower limb arterial thrombosis were described. In seven of these patients, six had fresh thrombi that preceded the NS diagnosis, while one had a history of NS for 14 years and previously underwent an emergency thrombectomy. Three of the seven patients eventually underwent above-knee amputations, and the other four underwent arterial revascularization with satisfactory recovery of lower-extremity perfusion. In addition to the seven patients mentioned above, the other two received successful anticoagulant treatment, as the thrombosis was present only in the popliteal artery.
Acute lower extremity arterial thrombosis is a rare but serious and potentially lethal complication in patients with NS, and early recognition and appropriate management are crucial for good patient outcomes.
From January 2011 and October 2022, we conducted a retrospective study of patients with NS and arterial thrombosis. Their clinical manifestations, imaging characteristics, treatments and outcomes were analyzed and compared, and a literature review was performed.
Nine adults with NS and acute lower limb arterial thrombosis were described. In seven of these patients, six had fresh thrombi that preceded the NS diagnosis, while one had a history of NS for 14 years and previously underwent an emergency thrombectomy. Three of the seven patients eventually underwent above-knee amputations, and the other four underwent arterial revascularization with satisfactory recovery of lower-extremity perfusion. In addition to the seven patients mentioned above, the other two received successful anticoagulant treatment, as the thrombosis was present only in the popliteal artery.
Acute lower extremity arterial thrombosis is a rare but serious and potentially lethal complication in patients with NS, and early recognition and appropriate management are crucial for good patient outcomes.
摘要：
背景：肾病综合征（NS）是一种与高凝状态相关的疾病。血栓栓塞事件是NS公认的并发症。静脉血栓形成是众所周知的，而动脉血栓形成，更严重的是，发生频率较低，主要在儿童文献中报道。这项研究的目的是了解这些罕见的成人NS与急性下肢动脉血栓形成相关的病例，并提请注意它们，以防止误诊和延误治疗。
方法：从2011年1月到2022年10月，我们对NS和动脉血栓形成的患者进行了回顾性研究。他们的临床表现，成像特性，治疗和结果进行了分析和比较，并进行了文献综述。
结果：描述了9名患有NS和急性下肢动脉血栓的成年人。在这些患者中，有七个，6人在NS诊断之前有新鲜的血栓，其中一人有14年的NS病史，以前曾接受过紧急血栓切除术。七名病人中的三名最终接受了膝盖以上截肢,其余4例接受动脉血运重建，下肢灌注恢复满意。除了上面提到的7名患者，另外两人接受了成功的抗凝治疗，因为血栓形成仅存在于the动脉中。
结论：急性下肢动脉血栓形成是NS患者的一种罕见但严重且可能致命的并发症，早期识别和适当的管理对于良好的患者预后至关重要。
方法：从2011年1月到2022年10月，我们对NS和动脉血栓形成的患者进行了回顾性研究。他们的临床表现，成像特性，治疗和结果进行了分析和比较，并进行了文献综述。
结果：描述了9名患有NS和急性下肢动脉血栓的成年人。在这些患者中，有七个，6人在NS诊断之前有新鲜的血栓，其中一人有14年的NS病史，以前曾接受过紧急血栓切除术。七名病人中的三名最终接受了膝盖以上截肢,其余4例接受动脉血运重建，下肢灌注恢复满意。除了上面提到的7名患者，另外两人接受了成功的抗凝治疗，因为血栓形成仅存在于the动脉中。
结论：急性下肢动脉血栓形成是NS患者的一种罕见但严重且可能致命的并发症，早期识别和适当的管理对于良好的患者预后至关重要。
