METHODS: We performed a systematic search using PubMed, Embase, and Web of Science databases for all articles reporting possible associated diseases with CPG. Pooled random-effects odds ratios (ORs) with 95% CI were calculated.
RESULTS: A total of 17 studies were included in this systematic review. Statistically significant association (p <0.05) with CPG has been demonstrated with atopic diseases: atopic dermatitis (pooled OR, 10.91; 95% CI, 3.65-32.67), allergic rhinitis (2.66; 1.12-6.27), asthma (3.23; 1.55-6.74); infectious diseases: hepatitis B (pooled OR, 2.15; 95% CI, 1.11-4.14); endocrine diseases: diabetes (pooled OR, 4.93; 95% CI, 1.13-21.56), type 1 diabetes (2.46; 2.16-2.81), type 2 diabetes (1.89; 1.34-2.68), hyperlipoproteinemia (2.90; 1.61-5.22); cardiovascular diseases: heart failure (pooled OR, 4.13; 95% CI, 1.15-14.91), hypertension (3.17; 1.56-6.45); respiratory system diseases: chronic obstructive pulmonary disease (pooled OR, 3.19; 95% CI, 1.42-7.16); urinary system diseases: chronic kidney disease (pooled OR, 4.16; 95% CI, 1.79-9.66); digestive system disease: inflammatory bowel disease (pooled OR, 2.06; 95% CI, 1.26-3.36); and others: osteoporosis (pooled OR, 3.08; 95% CI, 1.70-5.59), thyroid disease (1.70; 1.17-2.47).
CONCLUSIONS: CPG is associated with various systemic disorders. Recognition of comorbidities is critical to the appropriate management of affected patients.
方法:我们使用PubMed进行了系统搜索,Embase,和WebofScience数据库中所有报告与CPG可能相关疾病的文章。计算95%CI的集合随机效应比值比(OR)。
结果:本系统综述共纳入17项研究。已证明CPG与特应性疾病的统计学显着关联(P<0.05):特应性皮炎(合并OR,10.91;95%CI,3.65-32.67),过敏性鼻炎(2.66;1.12-6.27),哮喘(3.23;1.55-6.74);传染病:乙型肝炎(合并OR,2.15;95%CI,1.11-4.14);内分泌疾病:糖尿病(合并OR,4.93;95%CI,1.13-21.56),1型糖尿病2.46;2.16-2.81),2型糖尿病(1.89;1.34-2.68),高脂蛋白血症(2.90;1.61-5.22);心血管疾病:心力衰竭(合并OR,4.13;95%CI,1.15-14.91),高血压(3.17;1.56-6.45);呼吸系统疾病:慢性阻塞性肺疾病(合并OR,3.19;95%CI,1.42-7.16);泌尿系统疾病:慢性肾脏疾病(合并OR,4.16;95%CI,1.79-9.66);消化系统疾病:炎症性肠病(合并OR,2.06;95%CI,1.26-3.36);其他:骨质疏松症(合并OR,3.08;95%CI,1.70-5.59),甲状腺疾病(1.70;1.17-2.47)。
结论:CPG与各种系统性疾病有关。识别合并症对于适当管理受影响的患者至关重要。