Abstract：
BACKGROUND: Chronic prurigo (CPG) is an inflammatory skin disease. Comorbidities including dermatological, cardiovascular, and psychiatric diseases have been reported in patients with CPG; however, the evidence has not been systematically evaluated. We aim to summarize the comorbidities, discuss underlying pathogenesis, and highlight the evaluation of CPG patients.
METHODS: We performed a systematic search using PubMed, Embase, and Web of Science databases for all articles reporting possible associated diseases with CPG. Pooled random-effects odds ratios (ORs) with 95% CI were calculated.
RESULTS: A total of 17 studies were included in this systematic review. Statistically significant association (p <0.05) with CPG has been demonstrated with atopic diseases: atopic dermatitis (pooled OR, 10.91; 95% CI, 3.65-32.67), allergic rhinitis (2.66; 1.12-6.27), asthma (3.23; 1.55-6.74); infectious diseases: hepatitis B (pooled OR, 2.15; 95% CI, 1.11-4.14); endocrine diseases: diabetes (pooled OR, 4.93; 95% CI, 1.13-21.56), type 1 diabetes (2.46; 2.16-2.81), type 2 diabetes (1.89; 1.34-2.68), hyperlipoproteinemia (2.90; 1.61-5.22); cardiovascular diseases: heart failure (pooled OR, 4.13; 95% CI, 1.15-14.91), hypertension (3.17; 1.56-6.45); respiratory system diseases: chronic obstructive pulmonary disease (pooled OR, 3.19; 95% CI, 1.42-7.16); urinary system diseases: chronic kidney disease (pooled OR, 4.16; 95% CI, 1.79-9.66); digestive system disease: inflammatory bowel disease (pooled OR, 2.06; 95% CI, 1.26-3.36); and others: osteoporosis (pooled OR, 3.08; 95% CI, 1.70-5.59), thyroid disease (1.70; 1.17-2.47).
CONCLUSIONS: CPG is associated with various systemic disorders. Recognition of comorbidities is critical to the appropriate management of affected patients.
METHODS: We performed a systematic search using PubMed, Embase, and Web of Science databases for all articles reporting possible associated diseases with CPG. Pooled random-effects odds ratios (ORs) with 95% CI were calculated.
RESULTS: A total of 17 studies were included in this systematic review. Statistically significant association (p <0.05) with CPG has been demonstrated with atopic diseases: atopic dermatitis (pooled OR, 10.91; 95% CI, 3.65-32.67), allergic rhinitis (2.66; 1.12-6.27), asthma (3.23; 1.55-6.74); infectious diseases: hepatitis B (pooled OR, 2.15; 95% CI, 1.11-4.14); endocrine diseases: diabetes (pooled OR, 4.93; 95% CI, 1.13-21.56), type 1 diabetes (2.46; 2.16-2.81), type 2 diabetes (1.89; 1.34-2.68), hyperlipoproteinemia (2.90; 1.61-5.22); cardiovascular diseases: heart failure (pooled OR, 4.13; 95% CI, 1.15-14.91), hypertension (3.17; 1.56-6.45); respiratory system diseases: chronic obstructive pulmonary disease (pooled OR, 3.19; 95% CI, 1.42-7.16); urinary system diseases: chronic kidney disease (pooled OR, 4.16; 95% CI, 1.79-9.66); digestive system disease: inflammatory bowel disease (pooled OR, 2.06; 95% CI, 1.26-3.36); and others: osteoporosis (pooled OR, 3.08; 95% CI, 1.70-5.59), thyroid disease (1.70; 1.17-2.47).
CONCLUSIONS: CPG is associated with various systemic disorders. Recognition of comorbidities is critical to the appropriate management of affected patients.
摘要：
背景：慢性痒疹（CPG）是一种炎症性皮肤病。合并症，包括皮肤病，心血管,据报道，CPG患者患有精神疾病，然而,证据尚未得到系统评估。我们的目标是总结合并症，讨论潜在的发病机制，并强调对CPG患者的评估。
方法：我们使用PubMed进行了系统搜索，Embase,和WebofScience数据库中所有报告与CPG可能相关疾病的文章。计算95%CI的集合随机效应比值比(OR)。
结果：本系统综述共纳入17项研究。已证明CPG与特应性疾病的统计学显着关联（P<0.05）：特应性皮炎（合并OR，10.91；95%CI，3.65-32.67），过敏性鼻炎（2.66;1.12-6.27），哮喘（3.23;1.55-6.74）；传染病：乙型肝炎（合并OR，2.15；95%CI，1.11-4.14)；内分泌疾病：糖尿病(合并OR，4.93；95%CI，1.13-21.56），1型糖尿病2.46；2.16-2.81），2型糖尿病（1.89;1.34-2.68），高脂蛋白血症（2.90;1.61-5.22）；心血管疾病：心力衰竭（合并OR，4.13；95%CI，1.15-14.91），高血压（3.17;1.56-6.45）；呼吸系统疾病：慢性阻塞性肺疾病（合并OR，3.19；95%CI，1.42-7.16)；泌尿系统疾病：慢性肾脏疾病(合并OR，4.16；95%CI，1.79-9.66）；消化系统疾病：炎症性肠病（合并OR，2.06；95%CI，1.26-3.36)；其他：骨质疏松症(合并OR，3.08；95%CI，1.70-5.59），甲状腺疾病（1.70;1.17-2.47）。
结论：CPG与各种系统性疾病有关。识别合并症对于适当管理受影响的患者至关重要。
方法：我们使用PubMed进行了系统搜索，Embase,和WebofScience数据库中所有报告与CPG可能相关疾病的文章。计算95%CI的集合随机效应比值比(OR)。
结果：本系统综述共纳入17项研究。已证明CPG与特应性疾病的统计学显着关联（P<0.05）：特应性皮炎（合并OR，10.91；95%CI，3.65-32.67），过敏性鼻炎（2.66;1.12-6.27），哮喘（3.23;1.55-6.74）；传染病：乙型肝炎（合并OR，2.15；95%CI，1.11-4.14)；内分泌疾病：糖尿病(合并OR，4.93；95%CI，1.13-21.56），1型糖尿病2.46；2.16-2.81），2型糖尿病（1.89;1.34-2.68），高脂蛋白血症（2.90;1.61-5.22）；心血管疾病：心力衰竭（合并OR，4.13；95%CI，1.15-14.91），高血压（3.17;1.56-6.45）；呼吸系统疾病：慢性阻塞性肺疾病（合并OR，3.19；95%CI，1.42-7.16)；泌尿系统疾病：慢性肾脏疾病(合并OR，4.16；95%CI，1.79-9.66）；消化系统疾病：炎症性肠病（合并OR，2.06；95%CI，1.26-3.36)；其他：骨质疏松症(合并OR，3.08；95%CI，1.70-5.59），甲状腺疾病（1.70;1.17-2.47）。
结论：CPG与各种系统性疾病有关。识别合并症对于适当管理受影响的患者至关重要。
