PDF(Pubmed)
Abstract：
Systemic lupus erythematosus (SLE) is a heterogeneous chronic, multisystem, inflammatory autoimmune disorder with variable clinical features, with its manifestations being attributed to the presence of multiple autoantibodies and their subsequent autoimmune reactions. Multiple organs may be involved, with the kidneys, the joints, and the skin being the most common, increasing maternal and fetal morbidity and mortality. Our current article describes the case of a 32-year-old primigravida who was referred to our department after the detection of fetal bradycardia and the strong suspicion of an underlying cardiac abnormality. After a detailed fetal and maternal assessment, the diagnosis of SLE-associated fetal congenital heart block was established, and the appropriate management and treatment were provided, factors that led to the uncomplicated delivery and prompt successful management of an otherwise severely affected fetus. Our work, also, includes a detailed review of the accumulated evidence regarding the association between autoantibodies and congenital heart block, the available screening modalities of the condition, and its potential therapeutic interventions.
摘要：
系统性红斑狼疮(SLE)是一种异质性慢性,多系统，具有不同临床特征的炎症性自身免疫性疾病，其表现归因于多种自身抗体的存在及其随后的自身免疫反应。可能涉及多个器官，肾脏，关节，皮肤是最常见的，增加孕产妇和胎儿的发病率和死亡率。我们当前的文章描述了一名32岁的primigravida的病例，该病例在检测到胎儿心动过缓并强烈怀疑潜在的心脏异常后被转诊到我们部门。经过详细的胎儿和母体评估，诊断为SLE相关胎儿先天性心脏传导阻滞，并提供了适当的管理和治疗，导致简单分娩并迅速成功治疗其他严重影响的胎儿的因素。我们的工作,还,包括对有关自身抗体与先天性心脏传导阻滞之间关联的累积证据的详细回顾，病情的可用筛查方式，及其潜在的治疗干预措施。
