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Abstract：
This study aimed to evaluate the effect of COVID-19 outbreak on stroke admission by using a national database. A quasi-experimental, ecological study using the national database of Thailand was conducted. The study period was between January 2017 and August 2020 before and after COVID-19 outbreak starting from March 2020. Numbers of stroke admission were evaluated before and after the COVID-19 outbreak by an interrupted time series analysis for both pre- and post-COIVD-19 outbreak. There were 381,891 patients admitted throughout Thailand. Of those, 292,382 patients (76.56%) were admitted due to thrombotic stroke followed by hemorrhagic stroke (73,130 patients; 19.15%) and embolic stroke (16,379 patients; 4.29%). During pre-COVID-19 outbreak, all stroke subtypes had an increasing trend with a coefficient of 0.076 (p value < 0.001) for thrombotic stroke, 0.003 (p value < 0.001) for embolic stroke and 0.012 (p value = 0.025) for hemorrhagic stroke. The COVID-19 outbreak had significantly effect on reductions of incidence rates of thrombotic and hemorrhagic stroke with a coefficient of -2.412 (p value < 0.001) and -0.803 (p value = 0.023). The incidence rates of three stroke subtypes were increasing prior to the COVID-19 outbreak. The COVID-19 outbreak significantly impacts hospital admission rates of both thrombotic and hemorrhagic stroke subtypes.
摘要：
本研究旨在通过国家数据库评估COVID-19爆发对卒中入院的影响。一个准实验,利用泰国国家数据库进行了生态研究。研究期间为2017年1月至2020年8月，从2020年3月开始的COVID-19爆发前后。通过对COIVD-19爆发前后的中断时间序列分析，评估了COVID-19爆发前后的卒中入院人数。整个泰国有381,891名患者入院。其中,由于血栓性中风（73,130例；19.15％）和栓塞性中风（16,379例；4.29％），收治了292,382例患者（76.56％）。在COVID-19爆发前，所有卒中亚型均有增加趋势,血栓性卒中的系数为0.076(p值<0.001),栓塞性卒中为0.003（p值<0.001），出血性卒中为0.012（p值=0.025）。COVID-19的爆发对降低血栓性和出血性中风的发病率有显著影响，系数为-2.412(p值<0.001)和-0.803(p值=0.023)。在COVID-19爆发之前，三种卒中亚型的发病率正在增加。COVID-19疫情显著影响血栓性和出血性中风亚型的入院率。
