PDF(Pubmed)
Abstract：
UNASSIGNED: The correlation between gut microbiota and infections has garnered significant attention in previous studies; nevertheless, our understanding of the causal relationships and mechanisms between specific microbial species and infections remains limited.
UNASSIGNED: This study aimed to employ Mendelian randomization (MR) using single-nucleotide polymorphisms (SNPs) and genome-wide association study (GWAS) data of European ancestry to explore the genetic-level relationships between distinct types of gut microbiota and susceptibility to infections. Our analysis encompassed three prevalent infections: intestinal infections, pneumonia, and urinary tract infections, while concurrently examining various types of gut microbiota.
UNASSIGNED: We identified 18 protective gut microbiotas alongside 13 associated with increased infection risk. Particularly noteworthy are certain microbial communities capable of producing butyrate, such as the Ruminococcaceae and Lachnospiraceae families, which exhibited both favorable and unfavorable effects. Additionally, we observed a few certain communities linked to infection susceptibility, including ErysipelotrichaceaeUCG003 (OR = 0.13, 95% CI: 0.054-0.33, p = 1.24E-05), Collinsella (OR = 3.25, 95% CI: 2.00-5.27, p = 1.87E-06), and NB1n (OR = 1.24, 95% CI: 1.09-1.40, p = 1.12E-03).
UNASSIGNED: This study reveals complex relationships between gut microbiota and various infections. Our findings could potentially offer new avenues for exploring prevention and treatment strategies for infectious diseases.
UNASSIGNED: This study aimed to employ Mendelian randomization (MR) using single-nucleotide polymorphisms (SNPs) and genome-wide association study (GWAS) data of European ancestry to explore the genetic-level relationships between distinct types of gut microbiota and susceptibility to infections. Our analysis encompassed three prevalent infections: intestinal infections, pneumonia, and urinary tract infections, while concurrently examining various types of gut microbiota.
UNASSIGNED: We identified 18 protective gut microbiotas alongside 13 associated with increased infection risk. Particularly noteworthy are certain microbial communities capable of producing butyrate, such as the Ruminococcaceae and Lachnospiraceae families, which exhibited both favorable and unfavorable effects. Additionally, we observed a few certain communities linked to infection susceptibility, including ErysipelotrichaceaeUCG003 (OR = 0.13, 95% CI: 0.054-0.33, p = 1.24E-05), Collinsella (OR = 3.25, 95% CI: 2.00-5.27, p = 1.87E-06), and NB1n (OR = 1.24, 95% CI: 1.09-1.40, p = 1.12E-03).
UNASSIGNED: This study reveals complex relationships between gut microbiota and various infections. Our findings could potentially offer new avenues for exploring prevention and treatment strategies for infectious diseases.
摘要：
■肠道菌群与感染之间的相关性在以前的研究中引起了极大的关注；尽管如此，我们对特定微生物种类与感染之间的因果关系和机制的理解仍然有限.
■本研究旨在利用单核苷酸多态性（SNP）和欧洲血统的全基因组关联研究（GWAS）数据，利用孟德尔随机化（MR）来探索不同类型的肠道微生物群与感染易感性之间的遗传水平关系。我们的分析包括三种流行的感染：肠道感染，肺炎,尿路感染,同时检查各种类型的肠道微生物群。
■我们确定了18种保护性肠道微生物，以及13种与感染风险增加相关的微生物。特别值得注意的是某些能够产生丁酸的微生物群落，如Ruminocycaceae和Lachnospileaceae家族，表现出有利和不利的影响。此外,我们观察到一些与感染易感性有关的社区，包括ErysipelotricaceUCG003（OR=0.13，95％CI：0.054-0.33，p=1.24E-05），Collinsella（OR=3.25，95%CI：2.00-5.27，p=1.87E-06），和NB1n（OR=1.24，95%CI：1.09-1.40，p=1.12E-03）。
■这项研究揭示了肠道微生物群与各种感染之间的复杂关系。我们的发现可能为探索传染病的预防和治疗策略提供新的途径。
■本研究旨在利用单核苷酸多态性（SNP）和欧洲血统的全基因组关联研究（GWAS）数据，利用孟德尔随机化（MR）来探索不同类型的肠道微生物群与感染易感性之间的遗传水平关系。我们的分析包括三种流行的感染：肠道感染，肺炎,尿路感染,同时检查各种类型的肠道微生物群。
■我们确定了18种保护性肠道微生物，以及13种与感染风险增加相关的微生物。特别值得注意的是某些能够产生丁酸的微生物群落，如Ruminocycaceae和Lachnospileaceae家族，表现出有利和不利的影响。此外,我们观察到一些与感染易感性有关的社区，包括ErysipelotricaceUCG003（OR=0.13，95％CI：0.054-0.33，p=1.24E-05），Collinsella（OR=3.25，95%CI：2.00-5.27，p=1.87E-06），和NB1n（OR=1.24，95%CI：1.09-1.40，p=1.12E-03）。
■这项研究揭示了肠道微生物群与各种感染之间的复杂关系。我们的发现可能为探索传染病的预防和治疗策略提供新的途径。
