Abstract：
OBJECTIVE: In this study, the therapeutic effect of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in comparison to blue/red light combined with intralesional triamcinolone injection for severe inflammatory acne was evaluated and analyzed.
METHODS: One hundred and four cases of severe inflammatory acne were analyzed in this study. They were divided into two groups as control and observation groups, 52 cases in each group. The control group (group A) received red and blue light combined with triamcinolone injection and lidocaine injection (1:4), while the observation group (Group B) was treated with ALA-PDT. Finally, the therapeutic effect and the occurrence of adverse reactions were compared between the two groups.
RESULTS: After 2, 4 and 6 weeks, the effectiveness rates of group B was 28.85%, 75.00%, and 86.54%, respectively while it was 9.62%, 51.92%, and 69.23%, respectively in group A. The difference between A and B was statistically remarkable (χ2 = 6.1905, 5.9713, 4.5217, p = 0.0128, 0.0145, 0.0335 at p < 0.05). In addition, the incidence of adverse reactions in B was 5.77%, lower than A (32.69%). This difference between A and B was statistically remarkable (χ2 = 12.1333, p = 0.0005). After 2, 4, and 6 weeks of treatment, the number of residual lesions in the group B group was remarkably lower than group A (p < 0.01). There was remarkable difference in the incidence of pain, burning sensation, pigmentation and erythema between the two groups.
CONCLUSIONS: The therapeutic effect of ALA-PDT in the treatment of severe acne is better than red blue light combined with triamcinolone injection and lidocaine injection. In addition, ALA-PDT has an ideal effect in the treatment of severe acne.
METHODS: One hundred and four cases of severe inflammatory acne were analyzed in this study. They were divided into two groups as control and observation groups, 52 cases in each group. The control group (group A) received red and blue light combined with triamcinolone injection and lidocaine injection (1:4), while the observation group (Group B) was treated with ALA-PDT. Finally, the therapeutic effect and the occurrence of adverse reactions were compared between the two groups.
RESULTS: After 2, 4 and 6 weeks, the effectiveness rates of group B was 28.85%, 75.00%, and 86.54%, respectively while it was 9.62%, 51.92%, and 69.23%, respectively in group A. The difference between A and B was statistically remarkable (χ2 = 6.1905, 5.9713, 4.5217, p = 0.0128, 0.0145, 0.0335 at p < 0.05). In addition, the incidence of adverse reactions in B was 5.77%, lower than A (32.69%). This difference between A and B was statistically remarkable (χ2 = 12.1333, p = 0.0005). After 2, 4, and 6 weeks of treatment, the number of residual lesions in the group B group was remarkably lower than group A (p < 0.01). There was remarkable difference in the incidence of pain, burning sensation, pigmentation and erythema between the two groups.
CONCLUSIONS: The therapeutic effect of ALA-PDT in the treatment of severe acne is better than red blue light combined with triamcinolone injection and lidocaine injection. In addition, ALA-PDT has an ideal effect in the treatment of severe acne.
摘要：
目的：在本研究中，评价并分析了5-氨基酮戊酸光动力疗法(ALA-PDT)与蓝光/红光联合曲安奈德病灶内注射治疗重度炎性痤疮的疗效.
方法：对104例重度炎性痤疮进行分析。分为对照组和观察组,每组52例。对照组(A组)给予红蓝光联合曲安奈德注射液和利多卡因注射液(1:4),观察组(B组)采用ALA-PDT治疗。最后,比较两组患者的治疗效果及不良反应发生情况。
结果：在2、4和6周后，B组有效率为28.85%,75.00%,和86.54%，分别为9.62%，51.92%，和69.23%，A组与B组比较差异有统计学意义(χ2=6.1905、5.9713、4.5217,p=0.0128、0.0145、0.0335,p<0.05)。此外,B组不良反应发生率为5.77%,低于A（32.69%）。A和B之间的差异具有统计学意义（χ2=12.1333，p=0.0005）。治疗2、4和6周后，B组病灶残留数明显低于A组(p<0.01)。疼痛的发生率有显著差异，灼烧感,两组之间的色素沉着和红斑。
结论：ALA-PDT治疗重度痤疮的疗效优于红蓝光联合曲安奈德注射液和利多卡因注射液。此外,ALA-PDT治疗重度痤疮效果理想。
方法：对104例重度炎性痤疮进行分析。分为对照组和观察组,每组52例。对照组(A组)给予红蓝光联合曲安奈德注射液和利多卡因注射液(1:4),观察组(B组)采用ALA-PDT治疗。最后,比较两组患者的治疗效果及不良反应发生情况。
结果：在2、4和6周后，B组有效率为28.85%,75.00%,和86.54%，分别为9.62%，51.92%，和69.23%，A组与B组比较差异有统计学意义(χ2=6.1905、5.9713、4.5217,p=0.0128、0.0145、0.0335,p<0.05)。此外,B组不良反应发生率为5.77%,低于A（32.69%）。A和B之间的差异具有统计学意义（χ2=12.1333，p=0.0005）。治疗2、4和6周后，B组病灶残留数明显低于A组(p<0.01)。疼痛的发生率有显著差异，灼烧感,两组之间的色素沉着和红斑。
结论：ALA-PDT治疗重度痤疮的疗效优于红蓝光联合曲安奈德注射液和利多卡因注射液。此外,ALA-PDT治疗重度痤疮效果理想。
