Abstract：
OBJECTIVE: Is endometriosis detrimental to embryo implantation?
METHODS: A retrospective matched case-control study of women with a surgical or ultrasound diagnosis of endometriosis at Fondazione IRCCS Ca\'Granda Ospedale Maggiore Policlinico di Milano between 2015 and 2021. Women with endometriosis who underwent a \'freeze-all\' cycle during an IVF treatment were eligible to be included. They were matched to patients without the disease, who also underwent cryopreserved blastocyst transfer cycles, in a 1:1 ratio by age (±1 year), and number (=) and quality (±1 top versus low) of cryopreserved blastocysts. All women underwent single frozen embryo transfer, and assisted reproductive technology outcomes suggested by the Core Outcome Measure for Infertility Trials initiative were evaluated. The main outcome was the cumulative live birth rate per cycle.
RESULTS: One hundred and one women with endometriosis and 101 matched unaffected women were included. Cumulative live birth rate per cycle did not vary between women with and without endometriosis (50% versus 58%, respectively; P = 0.32). On the basis of the Kaplan-Meier analysis, the predicted success rates over four embryos transferred were also similar (74% versus 82%, respectively; P = 0.67).
CONCLUSIONS: In women with moderate or severe endometriosis, these retrospective results seem to indicate no or a limited effect of the disease on endometrial receptivity.
METHODS: A retrospective matched case-control study of women with a surgical or ultrasound diagnosis of endometriosis at Fondazione IRCCS Ca\'Granda Ospedale Maggiore Policlinico di Milano between 2015 and 2021. Women with endometriosis who underwent a \'freeze-all\' cycle during an IVF treatment were eligible to be included. They were matched to patients without the disease, who also underwent cryopreserved blastocyst transfer cycles, in a 1:1 ratio by age (±1 year), and number (=) and quality (±1 top versus low) of cryopreserved blastocysts. All women underwent single frozen embryo transfer, and assisted reproductive technology outcomes suggested by the Core Outcome Measure for Infertility Trials initiative were evaluated. The main outcome was the cumulative live birth rate per cycle.
RESULTS: One hundred and one women with endometriosis and 101 matched unaffected women were included. Cumulative live birth rate per cycle did not vary between women with and without endometriosis (50% versus 58%, respectively; P = 0.32). On the basis of the Kaplan-Meier analysis, the predicted success rates over four embryos transferred were also similar (74% versus 82%, respectively; P = 0.67).
CONCLUSIONS: In women with moderate or severe endometriosis, these retrospective results seem to indicate no or a limited effect of the disease on endometrial receptivity.
摘要：
目的：子宫内膜异位症对胚胎植入有害吗？
方法：对2015年至2021年在FondazioneIRCCSCa\'GrandaOspedaleMaggiorePoliclinicodiMilano手术或超声诊断为子宫内膜异位症的女性进行回顾性配对病例对照研究。子宫内膜异位症妇女在IVF治疗期间接受了“全冷冻”周期，符合纳入标准。他们与没有这种疾病的患者相匹配，他们还接受了冷冻保存的胚泡移植周期，年龄为1：1（±1岁），冷冻保存的胚泡的数量（=）和质量（±1顶部和底部）。所有女性都接受了单个冷冻胚胎移植，和辅助生殖技术的结果建议的不孕不育试验计划进行了评估。主要结果是每个周期的累积活产率。
结果：纳入了100名患有子宫内膜异位症的女性和101名匹配的未受影响的女性。每个周期的累积活产率在有子宫内膜异位症和无子宫内膜异位症的女性之间没有变化(50%对58%,分别为；P=0.32)。在Kaplan-Meier分析的基础上,四个胚胎移植的预测成功率也相似(74%对82%，分别为；P=0.67）。
结论：在患有中度或重度子宫内膜异位症的女性中，这些回顾性结果似乎表明该疾病对子宫内膜容受性没有影响或影响有限.
方法：对2015年至2021年在FondazioneIRCCSCa\'GrandaOspedaleMaggiorePoliclinicodiMilano手术或超声诊断为子宫内膜异位症的女性进行回顾性配对病例对照研究。子宫内膜异位症妇女在IVF治疗期间接受了“全冷冻”周期，符合纳入标准。他们与没有这种疾病的患者相匹配，他们还接受了冷冻保存的胚泡移植周期，年龄为1：1（±1岁），冷冻保存的胚泡的数量（=）和质量（±1顶部和底部）。所有女性都接受了单个冷冻胚胎移植，和辅助生殖技术的结果建议的不孕不育试验计划进行了评估。主要结果是每个周期的累积活产率。
结果：纳入了100名患有子宫内膜异位症的女性和101名匹配的未受影响的女性。每个周期的累积活产率在有子宫内膜异位症和无子宫内膜异位症的女性之间没有变化(50%对58%,分别为；P=0.32)。在Kaplan-Meier分析的基础上,四个胚胎移植的预测成功率也相似(74%对82%，分别为；P=0.67）。
结论：在患有中度或重度子宫内膜异位症的女性中，这些回顾性结果似乎表明该疾病对子宫内膜容受性没有影响或影响有限.
