PDF(Pubmed)
Abstract：
BACKGROUND Schwannomas are rare and benign tumors of the nerve sheath, composed of Schwann cells, and they are extremely rare in the nasal area. Here, we report a case that presented to our clinic as a growing nasal mass and was found to be a unilateral subcutaneous schwannoma. There have been a few previous cases reported of such patients having nasal obstruction, epistaxis, or other symptoms, but our patient did not. We stress the importance of considering schwannoma in the differential diagnosis of nasal masses, even in pediatric patients, and the role of histopathology differentiating it from other diagnoses such as neurofibroma. CASE REPORT Our patient was a 9-year-old girl with a painless nasal swelling on the nasal bridge that she first noticed 2 years ago, which started growing gradually and began to become firm. She was otherwise asymptomatic and had no relevant family history. Histopathology revealed an encapsulated spindle cell tumor with both hypo- and hyper-cellular areas, and immunohistochemistry showed that the tumor was strongly positive for S-100 and negative for both desmin and CD34, with blood vessels marking. A final diagnosis of schwannoma was made. CONCLUSIONS We presented a case of nasal septal schwannoma, emphasizing the importance of considering schwannoma in the differential diagnosis of nasal masses, and the role of histopathology to rule out other possible diagnoses.
摘要：
背景神经鞘瘤是一种罕见的神经鞘良性肿瘤，由施万细胞组成，它们在鼻腔区域非常罕见。这里,我们报告了一个病例，作为一个不断增长的鼻腔肿块，并被发现是一个单侧皮下神经鞘瘤。以前曾报道过一些此类患者患有鼻塞的病例，鼻出血,或其他症状，但我们的病人没有.我们强调在鼻部肿块的鉴别诊断中考虑神经鞘瘤的重要性，即使是儿科患者，以及组织病理学将其与其他诊断如神经纤维瘤区分开来的作用。病例报告我们的病人是一个9岁的女孩，她2年前第一次注意到鼻梁上有无痛的鼻肿胀，它开始逐渐增长，开始变得坚定。她在其他方面无症状，没有相关的家族史。组织病理学显示包囊的梭形细胞肿瘤具有低细胞和高细胞区域，免疫组织化学显示肿瘤S-100强阳性，结蛋白和CD34均阴性，并带有血管标记。最终诊断为神经鞘瘤。结论我们介绍了一例鼻中隔神经鞘瘤，强调在鼻部肿块的鉴别诊断中考虑神经鞘瘤的重要性，以及组织病理学在排除其他可能诊断方面的作用。
