Abstract：
OBJECTIVE: The aim of this study is to assess the precision of the Gleason score (GS) obtained through cognitive fusion-targeted biopsy (COG-TB) in comparison to transrectal ultrasonography-guided systematic biopsy (TRUS-SB), and to identify factors that can predict Gleason score upgrading (GSU) in a cohort of Chinese patients.
METHODS: A final enrollment of 245 patients was recorded. Between 2020 and 2022, 132 patients underwent TRUS-SB, and 113 patients underwent COG-TB. The Chi-square test was performed to analyze the variation in downgrading, concordance, and upgrading between TRUS-SB and COG-TB. Multivariable analyses were performed to seek factors predicting Gleason score upgrading. Finally, a model which utilizes multivariable logistic regression was developed to predict the likelihood of GSU.
RESULTS: The concordance for TRUS-SB and COG-TB were 42.4% and 65.5%, respectively. TRUS-SB and COG-TB exhibited notable disparities in downgrading, concordance, and upgrading. Age, prostate volume, body mass index (BMI), and the biopsy modality were significant predictive factors.
CONCLUSIONS: COG-TB can significantly increase concordance with final histopathology. Age, prostate volume, BMI, and the biopsy modality were predictive factors of GSU.
METHODS: A final enrollment of 245 patients was recorded. Between 2020 and 2022, 132 patients underwent TRUS-SB, and 113 patients underwent COG-TB. The Chi-square test was performed to analyze the variation in downgrading, concordance, and upgrading between TRUS-SB and COG-TB. Multivariable analyses were performed to seek factors predicting Gleason score upgrading. Finally, a model which utilizes multivariable logistic regression was developed to predict the likelihood of GSU.
RESULTS: The concordance for TRUS-SB and COG-TB were 42.4% and 65.5%, respectively. TRUS-SB and COG-TB exhibited notable disparities in downgrading, concordance, and upgrading. Age, prostate volume, body mass index (BMI), and the biopsy modality were significant predictive factors.
CONCLUSIONS: COG-TB can significantly increase concordance with final histopathology. Age, prostate volume, BMI, and the biopsy modality were predictive factors of GSU.
摘要：
目的：本研究的目的是评估通过认知融合靶向活检（COG-TB）获得的Gleason评分（GS）与经直肠超声引导的系统活检（TRUS-SB）相比，并确定可以预测中国患者队列中Gleason评分升级（GSU）的因素。
方法：最终纳入245例患者。在2020年至2022年之间，132名患者接受了TRUS-SB，113例患者接受COG-TB治疗。进行卡方检验来分析降级的变化，和谐，以及TRUS-SB和COG-TB之间的升级。进行多变量分析以寻求预测Gleason评分提升的因素。最后,建立了一个利用多变量逻辑回归的模型来预测GSU的可能性。
结果：TRUS-SB和COG-TB的一致性分别为42.4%和65.5%，分别。TRUS-SB和COG-TB在降级方面表现出显著差异，和谐，和升级。年龄,前列腺体积,体重指数（BMI），活检方式是重要的预测因素。
结论：COG-TB可显著增加与最终组织病理学的一致性。年龄,前列腺体积,BMI,活检方式是GSU的预测因素。
方法：最终纳入245例患者。在2020年至2022年之间，132名患者接受了TRUS-SB，113例患者接受COG-TB治疗。进行卡方检验来分析降级的变化，和谐，以及TRUS-SB和COG-TB之间的升级。进行多变量分析以寻求预测Gleason评分提升的因素。最后,建立了一个利用多变量逻辑回归的模型来预测GSU的可能性。
结果：TRUS-SB和COG-TB的一致性分别为42.4%和65.5%，分别。TRUS-SB和COG-TB在降级方面表现出显著差异，和谐，和升级。年龄,前列腺体积,体重指数（BMI），活检方式是重要的预测因素。
结论：COG-TB可显著增加与最终组织病理学的一致性。年龄,前列腺体积,BMI,活检方式是GSU的预测因素。
